Potential role for interleukin-1 in the pathophysiology of ulcerative colitis.

@article{Wardle1994PotentialRF,
  title={Potential role for interleukin-1 in the pathophysiology of ulcerative colitis.},
  author={T. Wardle and L. Turnberg},
  journal={Clinical science},
  year={1994},
  volume={86 5},
  pages={
          619-26
        }
}
1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2, leukotriene C4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome and histologically normal mucosa. 2. Addition of interleukin-1 stimulated release of greater quantities of all these inflammatory mediators, including interleukin-1 itself, from inflamed and normal mucosa. 3. Blockade of cyclo… Expand
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