Potential role for interleukin-1 in the pathophysiology of ulcerative colitis.

  title={Potential role for interleukin-1 in the pathophysiology of ulcerative colitis.},
  author={T. Wardle and L. Turnberg},
  journal={Clinical science},
  volume={86 5},
1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2, leukotriene C4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome and histologically normal mucosa. 2. Addition of interleukin-1 stimulated release of greater quantities of all these inflammatory mediators, including interleukin-1 itself, from inflamed and normal mucosa. 3. Blockade of cyclo… Expand
27 Citations
Platelet-Activating Factor, a Critical Mediator in the Pathogenesis of Dextran Sulfate Sodium-Induced Colitis in Rats
Key role of mast cells and their major secretory products in inflammatory bowel disease.
  • S. He
  • Biology, Medicine
  • World journal of gastroenterology
  • 2004
Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor.
Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation.
Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis.
  • H. Lohi, S. Mäkelä, +4 authors J. Kere
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2002