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Hydroxymethylglutaryl-CoA Synthase
Known as:
HMG coA synthase
, Hydroxymethylglutaryl CoA Synthase
, HMG-CoA synthase
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An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis…
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National Institutes of Health
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Related topics
Related topics
12 relations
Narrower (1)
3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
HMGCL gene
HMGCLL1 gene
HMGCS1 gene
In Blood
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes
W. Siefken
,
H. Höppner
,
I. R. Harris
Experimental Dermatology
2000
Corpus ID: 41498691
Abstract: Cholesterol synthesis is essential for homeostasis of the epidermis, being required for both cell division and…
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1997
1997
The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
G. Arias
,
G. Asins
,
F. Hegardt
,
D. Serra
Archives of Biochemistry and Biophysics
1997
Corpus ID: 28368499
The influence of fasting/refeeding and insulin treatment on ketogenesis in 12-day-old suckling rats was studied in intestine and…
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Review
1995
Review
1995
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in liver and intestine from the rat.
F. Hegardt
Biochemical Society Transactions
1995
Corpus ID: 31766966
The enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyses the condensation of acetoacetyl-CoA and acetyl-CoA to form…
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Highly Cited
1992
Highly Cited
1992
Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase in a tobacco mutant that overproduces sterols.
L. Gondet
,
T. Weber
,
P. Maillot-Vernier
,
P. Benveniste
,
T. Bach
Biochemical and Biophysical Research…
1992
Corpus ID: 12126245
1990
1990
Evidence for substrate channeling in the early steps of cholesterogenesis.
H. Miziorko
,
F. Laib
,
C. Behnke
Journal of Biological Chemistry
1990
Corpus ID: 39196320
1985
1985
Active-site-directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A.
H. Miziorko
,
C. Behnke
Biochemistry
1985
Corpus ID: 29585857
3-Chloropropionyl coenzyme A (3-chloropropionyl-CoA) irreversibly inhibits avian liver 3-hydroxy-3-methylglutaryl-CoA synthase…
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1981
1981
Interrelationships between 3-hydroxy-3-methylglutaryl-CoA synthase, acetoacetyl-CoA and ketogenesis.
L. Menahan
,
W. T. Hron
,
Doloris G. Hinkelman
,
H. Miziorko
European Journal of Biochemistry
1981
Corpus ID: 10746839
Kinetic and physical approaches have been employed to investigate the binding of acetoacetyl-CoA to hydroxymethylglutaryl-CoA…
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1980
1980
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase and the regulation of sterol synthesis in tissue culture cells.
C. Ramachandran
,
S. Gray
,
G. Melnykovych
Biochimica et Biophysica Acta
1980
Corpus ID: 1799448
Highly Cited
1975
Highly Cited
1975
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver.
W. Reed
,
D. Clinkenbeard
,
M. Lane
Journal of Biological Chemistry
1975
Corpus ID: 6773139
Highly Cited
1968
Highly Cited
1968
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
D. Williamson
,
M. Bates
,
H. Krebs
Biochemical Journal
1968
Corpus ID: 6056537
1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than…
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