FAQ

Hydroxymethylglutaryl-CoA Synthase

Known as: HMG coA synthase, Hydroxymethylglutaryl CoA Synthase, HMG-CoA synthase 
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
0102019722017

Related topics

Related topics

14 relations

Narrower (1)

3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
HMGCL geneHMGCLL1 geneHMGCS1 geneIn Blood
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Hydroxymethylglutaryl-CoA Synthase
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
hydroxymethylglutaryl-CoA synthase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli
BACKGROUND Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
A screening program for bioactive compounds from marine cyanobacteria led to the isolation of jamaicamides A-C. Jamaicamide A is… (More)
Is this relevant?
2004
2004
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.
Curacin A (1) is a potent cancer cell toxin obtained from strains of the tropical marine cyanobacterium Lyngbya majuscula found… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in…
We compared the ability of rat and human hepatocytes to respond to fenofibric acid and a novel potent phenylacetic acid… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.
The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)-pyruvate pathway are alternative routes for the biosynthesis of… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • table 1
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.
Membrane physiology, plasma lipid levels, and intracellular sterol homeostasis are regulated by both fatty acids and cholesterol… (More)
Is this relevant?
1998
1998
Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear…
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
Fatty acids induce an increase in the transcription of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase gene… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid… (More)
Is this relevant?