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Hydroxymethylglutaryl-CoA Synthase

Known as: HMG coA synthase, Hydroxymethylglutaryl CoA Synthase, HMG-CoA synthase 
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (1)

3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
HMGCL geneHMGCLL1 geneHMGCS1 geneIn Blood

Papers overview

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2000
2000
Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes
Abstract: Cholesterol synthesis is essential for homeostasis of the epidermis, being required for both cell division and… 
1997
1997
The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
The influence of fasting/refeeding and insulin treatment on ketogenesis in 12-day-old suckling rats was studied in intestine and… 
Review
1995
Review
1995
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in liver and intestine from the rat.
The enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyses the condensation of acetoacetyl-CoA and acetyl-CoA to form… 
Highly Cited
1992
Highly Cited
1992
Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase in a tobacco mutant that overproduces sterols.
1990
1990
Evidence for substrate channeling in the early steps of cholesterogenesis.
1985
1985
Active-site-directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A.
3-Chloropropionyl coenzyme A (3-chloropropionyl-CoA) irreversibly inhibits avian liver 3-hydroxy-3-methylglutaryl-CoA synthase… 
1981
1981
Interrelationships between 3-hydroxy-3-methylglutaryl-CoA synthase, acetoacetyl-CoA and ketogenesis.
Kinetic and physical approaches have been employed to investigate the binding of acetoacetyl-CoA to hydroxymethylglutaryl-CoA… 
1980
1980
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase and the regulation of sterol synthesis in tissue culture cells.
Highly Cited
1975
Highly Cited
1975
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver.
Highly Cited
1968
Highly Cited
1968
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than… 
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