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Hydroxymethylglutaryl-CoA Synthase

Known as: HMG coA synthase, Hydroxymethylglutaryl CoA Synthase, HMG-CoA synthase 
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis… Expand
National Institutes of Health

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Related topics

12 relations

Narrower (1)

3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
HMGCL geneHMGCLL1 geneHMGCS1 geneIn Blood
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Papers overview

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2013
2013
Liver Fatty Acid Binding Protein Gene-Ablation Exacerbates Weight Gain in High-Fat Fed Female Mice
Loss of liver fatty acid binding protein (L-FABP) decreases long chain fatty acid uptake and oxidation in primary hepatocytes and… Expand
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2013
2013
Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.
OBJECTIVES The mechanism of alcohol-induced pancreatic damage is unclear. The aim of this study was to clarify the effects of… Expand
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2010
2010
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
Acetoacetyl-CoA is the precursor of 3-hydroxy-3-methylglutaryl (HMG)-CoA in the mevalonate pathway, which is essential for… Expand
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Highly Cited
2004
Highly Cited
2004
New insights into protein S-nitrosylation. Mitochondria as a model system.
The biological effects of nitric oxide (NO) are in significant part mediated through S-nitrosylation of cysteine thiol. Work on… Expand
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2000
2000
Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes.
Cholesterol synthesis is essential for homeostasis of the epidermis, being required for both cell division and differentiation… Expand
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1998
1998
Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7…
Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol… Expand
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1997
1997
The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.
The influence of fasting/refeeding and insulin treatment on ketogenesis in 12-day-old suckling rats was studied in intestine and… Expand
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Review
1995
Review
1995
Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in liver and intestine from the rat.
The enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyses the condensation of acetoacetyl-CoA and acetyl-CoA to form… Expand
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1989
1989
Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase.
The effects of oleic acid on the activities of cytosolic HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) synthase, AcAc-CoA (acetoacetyl… Expand
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1968
1968
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than… Expand
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