Hydroxychloroquine

Known as: Hydroxychlorochin, 2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol, 7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline 
A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy… (More)
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Review
2011
Review
2011
Autophagy is an evolutionarily conserved, intracellular self-defense mechanism in which organelles and proteins are sequestered… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of… (More)
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Highly Cited
2007
Highly Cited
2007
CONTEXT Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Hydroxychloroquine (HCQ) is often needed to manage disease activity in systemic lupus erythematosus (SLE) during… (More)
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Highly Cited
2003
Highly Cited
2003
Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ… (More)
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Highly Cited
2002
Highly Cited
2002
Prothrombotic properties of antiphospholipid (aPL) antibodies may be explained in part by their ability to enhance the activation… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Previous studies have demonstrated that human monoclonal and polyclonal anticardiolipin antibodies have thrombogenic… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Rheumatoid arthritis is a common disease that causes substantial morbidity and mortality. The responses of patients… (More)
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