Hydroxychloroquine

Known as: Hydroxychlorochin, 2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol, 7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline 
A 4-aminoquinoline with immunosuppressive, antiautophagy, and antimalarial activities. Although the precise mechanism of action is unknown… (More)
National Institutes of Health

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28 relations

Broader (3)

AntimalarialsChloroquineEnzyme Inhibitors
Antirheumatic AgentsDrug AllergyHydroxychloroquine SulfateHydroxychloroquine Sulfate 200 MG Oral Tablet
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Narrower (2)

Plaquenildesethylhydroxychloroquine

Papers overview

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Highly Cited
2014
Highly Cited
2014
A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy… (More)
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Review
2011
Review
2011
Principles and current strategies for targeting autophagy for cancer treatment.
Autophagy is an evolutionarily conserved, intracellular self-defense mechanism in which organelles and proteins are sequestered… (More)
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Highly Cited
2009
Highly Cited
2009
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
BACKGROUND New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of… (More)
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Highly Cited
2007
Highly Cited
2007
Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis.
CONTEXT Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of… (More)
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Highly Cited
2006
Highly Cited
2006
Hydroxychloroquine in lupus pregnancy.
OBJECTIVE Hydroxychloroquine (HCQ) is often needed to manage disease activity in systemic lupus erythematosus (SLE) during… (More)
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Highly Cited
2003
Highly Cited
2003
Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal… (More)
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Highly Cited
2002
Highly Cited
2002
Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy.
BACKGROUND The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ… (More)
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Highly Cited
2002
Highly Cited
2002
Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies.
Prothrombotic properties of antiphospholipid (aPL) antibodies may be explained in part by their ability to enhance the activation… (More)
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Highly Cited
1997
Highly Cited
1997
Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice.
BACKGROUND Previous studies have demonstrated that human monoclonal and polyclonal anticardiolipin antibodies have thrombogenic… (More)
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Highly Cited
1996
Highly Cited
1996
Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.
BACKGROUND Rheumatoid arthritis is a common disease that causes substantial morbidity and mortality. The responses of patients… (More)
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