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Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million… Expand Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid… Expand ABSTRACT Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores… Expand BackgroundSevere acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective… Expand
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has… Expand Widespread use of antimalarial agents can profoundly influence the evolution of the human malaria parasite Plasmodium falciparum… Expand Malaria caused by Plasmodium falciparum, a protozoan parasite of the blood, is responsible for up to 2.7 million deaths yearly… Expand Between 1978 and 1988 Plasmodium falciparum resistance to chloroquine has been reported in all countries of tropical Africa… Expand The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb… Expand Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is… Expand