Skip to search formSkip to main contentSkip to account menu

Hepatocyte Nuclear Factor 3-alpha

Known as: Forkhead Box Protein A1, HNF-3A Transcription Factor, TCF-3A 
Hepatocyte nuclear factor 3-alpha (472 aa, ~49 kDa) is encoded by the human FOXA1 gene. This protein plays a role in the modulation of transcription.
National Institutes of Health

Related topics

Related topics

18 relations
Cell NucleusDNA-Binding ProteinsFOXA1 geneForkhead Box

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance
Purpose: To identify molecular factors that determine duration of response to EGFR tyrosine kinase inhibitors and to identify… 
Highly Cited
2015
Highly Cited
2015
Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.
Highly Cited
2013
Highly Cited
2013
FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells.
The forkhead protein FoxA1 has functions other than a pioneer factor, in that its depletion brings about a significant… 
Highly Cited
2012
Highly Cited
2012
High Resolution Genome Wide Binding Event Finding and Motif Discovery Reveals Transcription Factor Spatial Binding Constraints
An essential component of genome function is the syntax of genomic regulatory elements that determine how diverse transcription… 
Highly Cited
2011
Highly Cited
2011
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Breast cancer is a heterogeneous disease and several distinct subtypes exist based on differential gene expression patterns… 
Highly Cited
2008
Highly Cited
2008
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is… 
Highly Cited
2007
Highly Cited
2007
FOXA1 Expression in Breast Cancer—Correlation with Luminal Subtype A and Survival
Purpose: FOXA1, a forkhead family transcription factor, is essential for optimum expression of ∼50% of estrogen receptor α (ER… 
Highly Cited
2005
Highly Cited
2005
The initiation of liver development is dependent on Foxa transcription factors
The specification of the vertebrate liver is thought to occur in a two-step process, beginning with the establishment of… 
Highly Cited
1992
Highly Cited
1992
A transcriptional hierarchy involved in mammalian cell-type specification
ALTHOUGH transcriptional hierachies have been extensively studied in invertebrates, their involvement in mammalian cell-type… 
Highly Cited
1991
Highly Cited
1991
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
By analysis of cDNA clones that cross-hybridized with a portion of the cDNA encoding the recently described rat protein… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)