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CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
TLDR
Breast cancer cells with CD44+/CD24- subpopulation express higher levels of proinvasive genes and have highly invasive properties, however, this phenotype is not sufficient to predict capacity for pulmonary metastasis.
Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α
TLDR
A molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERα, and inhibition of tamoxifen-induced apoptotic regression is defined.
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
TLDR
It is shown that NF-κB suppresses the expression of epithelial specific genes E-cadherin and desmoplakin and induces theexpression of the mesenchymal specific gene vimentin and the dependence of MCF10A/p65 cells to Z EB-1 and ZEB-2 for cell cycle progression or survival is suggested.
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
TLDR
It is shown that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodIMers on response elements.
Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
TLDR
Since ER inhibits the constitutive as well as inducible activation function of NF-kappaB in a dose-dependent manner, it is proposed that breast cancers that lack functional ER overexpress NF- kappaB-regulated genes.
NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4*
TLDR
It is demonstrated that NF-κB regulates the motility of breast cancer cells by directly up-regulating the expression of CXCR4 and the SDF-1α-mediated migration is observed with cancer cells that metastasized to the lungs.
RARs and RXRs: evidence for two autonomous transactivation functions (AF‐1 and AF‐2) and heterodimerization in vivo.
TLDR
It is reported that the AB regions of RAR alpha, beta and gamma, as well as those of RXR alpha and Gamma, contain an autonomous, ligand‐independent activation function, AF‐1, which can efficiently synergize with AF‐2s, and that RARs and RXRs preferentially heterodimerize in solution in cultured cells in vivo, through the dimerization interface present in their E region.
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
TLDR
It is proposed that the clinical course of ERα-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor micro RNAs and oncogenic microRNAs, and a negative-regulatory loop controlling E2 response through microRN as well as differences in E1-induced transcriptome and proteome.
PROGgeneV2: enhancements on the existing database
TLDR
With added datasets PROGgeneV2 is the most comprehensive survival analysis tool available and will continue to be useful for the scientific community for formulating research hypotheses and designing mechanistic studies.
Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment
TLDR
Tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors, and high degree of stromal expression was significantly associated with best disease-free survival and a trend for overall survival.
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