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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Transcriptional regulatory code of a eukaryotic genome
An initial map of yeast's transcriptional regulatory code is constructed by identifying the sequence elements that are bound by regulators under various conditions and that are conserved among Saccharomyces species.
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
Polycomb complexes repress developmental regulators in murine embryonic stem cells
It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
An improved map of conserved regulatory sites for Saccharomyces cerevisiae
- K. MacIsaac, Ting Wang, D. B. Gordon, D. Gifford, G. Stormo, E. Fraenkel
- BiologyBMC Bioinformatics
- 1 March 2006
Improved versions of two conservation-based motif discovery algorithms, PhyloCon and Converge, are reported, which improve the ability to identify the specificity of transcriptional regulators from genome-wide chromatin immunoprecipitation data.
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
Overcast: reliable multicasting with on overlay network
- John Jannotti, D. Gifford, K. Johnson, M. Kaashoek, J. O'Toole
- Computer Science, BusinessOSDI
- 22 October 2000
Simulations indicate that Overcast quickly builds bandwidth-efficient distribution trees that, compared to IP Multicast, provide 70%-100% of the total bandwidth possible, at a cost of somewhat less than twice the network load.
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
This work used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets.