• Publications
  • Influence
Genome-wide analysis of estrogen receptor binding sites
All estrogen receptor and RNA polymerase II binding sites are mapped on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells, and distinct temporal mechanisms of estrogen-mediated gene regulation are demonstrated.
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
It is found that drug-resistant cancers still recruit ER to the chromatin, but that ER binding is a dynamic process, with the acquisition of unique ER-binding regions in tumours from patients that are likely to relapse.
Pioneer transcription factors: establishing competence for gene expression.
The field is reviewed and how pioneer factors may enable cellular reprogramming is described, which can passively enhance transcription by reducing the number of additional factors that are needed to bind the DNA, culminating in activation.
Model-based analysis of tiling-arrays for ChIP-chip
  • W. Johnson, Wei Li, X. Liu
  • Computer Science
    Proceedings of the National Academy of Sciences
  • 15 August 2006
A fast and powerful analysis algorithm to reliably detect regions enriched by transcription factor chromatin immunoprecipitation on Affymetrix tiling arrays (ChIP-chip), developed in open-source Python and available at http://chip.dfci.harvard.edu/∼wli/MAT.
Evaluating the Effectiveness of Premarital Prevention Programs: A Meta‐Analytic Review of Outcome Research
It is suggested that premarital prevention programs are generally effective in producing immediate and short-term gains in interpersonal skills and overall relationship quality and that these improvements are significantly better than nonintervention couples in these areas.
A CTCF-independent role for cohesin in tissue-specific transcription.
The data show that cohesin cobinds across the genome with transcription factors independently of CTCF, plays a functional role in estrogen-regulated transcription, and may help to mediate tissue-specific transcriptional responses via long-range chromosomal interactions.