Hemoglobin Subunit Beta

Known as: Beta-Globin, Hemoglobin Beta Chain 
Hemoglobin subunit beta (147 aa, ~16 kDa) is encoded by the human HBB1 gene. This protein plays a role in the transport of oxygen to tissues of the… (More)
National Institutes of Health

Related topics

Related topics

10 relations
Cellular MembraneCooley's anemiaErythrocytesHBB gene
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Papers overview

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Highly Cited
2006
Highly Cited
2006
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus.
CTCF (CCCTC-binding factor) binds sites around the mouse beta-globin locus that spatially cluster in the erythroid cell nucleus… (More)
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Review
2004
Review
2004
An important role of Nrf2-ARE pathway in the cellular defense mechanism.
The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and… (More)
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Highly Cited
2000
Highly Cited
2000
Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods.
Four quantitative reverse transcription-PCR (RT-PCR) methods were compared to evaluate the time course of mRNA formation and… (More)
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Highly Cited
2000
Highly Cited
2000
Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon
Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are… (More)
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Highly Cited
2000
Highly Cited
2000
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin.
The stable introduction of a functional beta-globin gene in haematopoietic stem cells could be a powerful approach to treat beta… (More)
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Highly Cited
1999
Highly Cited
1999
The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators
An insulator is a DNA sequence that can act as a barrier to the influences of neighboring cis-acting elements, preventing gene… (More)
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Highly Cited
1995
Highly Cited
1995
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.
Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-rich sequences within their 3' untranslated… (More)
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Highly Cited
1989
Highly Cited
1989
Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.
Denaturing gradient gel electrophoresis (DGGE) can be used to distinguish two DNA molecules that differ by as little as a single… (More)
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Highly Cited
1986
Highly Cited
1986
Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes.
Allelic sequence variation has been analysed by synthetic oligonucleotide hybridization probes which can detect single base… (More)
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Highly Cited
1978
Highly Cited
1978
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.
Restriction endonuclease mapping of the human globin genes revealed a genetic variation in a Hpa I recognition site about 5000… (More)
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