• Publications
  • Influence
Coagulation, fibrinolysis, and fibrin deposition in acute lung injury
  • S. Idell
  • Medicine
  • Critical care medicine
  • 1 April 2003
TLDR
The success of anticoagulant or fibrinolytic strategies designed to reverse the abnormalities of local fibrin turnover in acute lung injury supports the inference that abnormalities of coagulation, fibinolysis, andfibrin deposition have a critical role in the pathogenesis of acute lung Injury. Expand
Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.
TLDR
It is concluded that abnormalities that result in enhanced coagulation and depressed fibrinolysis, thereby predisposing to alveolar fibrin deposition, occur in theAlveolar lining fluids from patients with ARDS. Expand
Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons.
TLDR
The results show that TF-FVIIa complex contributes to organ injury in septic primates in part through selective stimulation of proinflammatory cytokine release and fibrin deposition. Expand
Angiotensin converting enzyme in bronchoalveolar lavage in ARDS.
TLDR
It was concluded that BAL ACE is elevated in some ARDS patients, especially those with infectious causes of lung injury, and may reflect endothelial damage or local increase in ACE production in response to sepsis. Expand
Endothelium and disordered fibrin turnover in the injured lung: Newly recognized pathways
  • S. Idell
  • Medicine
  • Critical care medicine
  • 1 May 2002
TLDR
Local abnormalities of fibrin turnover in the injured lung recapitulate the systemic changes observed in sepsis and defines another feedback loop that could amplify local fibrinolysis and other uPA- or uPAR-mediated cellular responses, including cellular proteolysis, proliferation, and directed cellular migration. Expand
Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture.
TLDR
Data indicate that OprF contributes to bacterial adherence to A549 epithelial cells and could facilitate Pseudomonas interactions with the epithelium, including colonization of the airway epithelia or the initiation of pulmonary infection. Expand
Pathophysiologic, morphometric, and biochemical studies of the premature baboon with bronchopulmonary dysplasia.
TLDR
The pathologic, morphometric, and biochemical patterns seen in premature baboons with and without bronchopulmonary dysplasia probably represent those seen in human neonates with mild to moderate clinical BPD who survive. Expand
Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage.
TLDR
Changes in procoagulant and fibrinolytic activities in serial bronchoalveolar lavage of baboons with evolving diffuse alveolar damage induced by exposure to 100% O2 correlated with quantitatively increasedAlveolar fibrin deposition demonstrated by histologic and morphometric analyses. Expand
Anticoagulants for acute respiratory distress syndrome: can they work?
  • S. Idell
  • Medicine
  • American journal of respiratory and critical care…
  • 15 August 2001
Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure.
TLDR
Blockade of factor X binding to the tissue factor-factor VIIa complex attenuates lung and organ injuries in established E. coli sepsis by attenuating the neutrophilic response and inflammatory pathways. Expand
...
1
2
3
4
5
...