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A comprehensive set of sequence analysis programs for the VAX
TLDR
A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system. Expand
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
TLDR
Prenatal male and female reproductive tract development can occur in the absence of estradiol receptor-mediated responsiveness, and the uteri and vagina do not respond in the animals with the estrogen receptor gene disruption. Expand
Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
TLDR
The generation of mice lacking estrogen receptor beta (ERbeta -/-) is described by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells to determine the role of ERbeta in bone and cardiovascular homeostasis. Expand
Mouse models of diabetic nephropathy.
TLDR
This interim report and an online supplement detail the progress made toward a complete murine model of human diabetic kidney disease and the critical analysis of existing murine models, which substantially enhances the understanding of this disease process. Expand
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
TLDR
COX-1-deficient mice provide a useful model to distinguish the physiological roles of COx-1 and COX-3, the target enzymes for the widely used nonsteroidal anti-inflammatory drugs. Expand
Male–female differences in fertility and blood pressure in ACE-deficient mice
TLDR
The role of the Ace gene is investigated using mice generated to carry an insertional mutation that is designed to inactivate both forms of ACE and the fertility of homozygous male mutants was greatly reduced. Expand
An Animal Model for Cystic Fibrosis Made by Gene Targeting
TLDR
Mice homozygous for the disrupted gene display many features common to young human cystic fibrosis patients, including failure to thrive, meconium ileus, alteration of mucous and serous glands, and obstruction of glandlike structures with inspissated eosinophilic material. Expand
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.
TLDR
Comparisons between the current eNOS mutant mice and previously generated inducible nitric oxide synthase mutants showed that homozygous mutants for the latter differ in having unaltered blood pressures and heart rates; both are susceptible to lipopolysaccharide-induced death. Expand
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.
TLDR
To explore the physiological roles of transforming growth factor alpha (TGF alpha), the mouse gene was disrupted by homologous recombination in embryonic stem cells by knocking out the homozygous mutant mice, which displayed pronounced waviness of the whiskers and fur, accompanied by abnormal curvature, disorientation, and misalignment of the hair follicles. Expand
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
TLDR
Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid, however, they develop severe nephropathy and are susceptible to peritonitis. Expand
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