• Publications
  • Influence
A comprehensive set of sequence analysis programs for the VAX
The University of Wisconsin Genetics Computer Group (UWGCG) has been organized to develop computational tools for the analysis and publication of biological sequence data. A group of programs thatExpand
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Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory drugs. To study the physiologicalExpand
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Male–female differences in fertility and blood pressure in ACE-deficient mice
ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin1. The geneExpand
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An Animal Model for Cystic Fibrosis Made by Gene Targeting
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR). ToExpand
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Single-copy transgenic mice with chosen-site integration.
We describe a general way of introducing transgenes into the mouse germ line for comparing different sequences without the complications of variation in copy number and insertion site. The methodExpand
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Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli. COX-2 is generallyExpand
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TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.
To explore the physiological roles of transforming growth factor alpha (TGF alpha), we disrupted the mouse gene by homologous recombination in embryonic stem cells. Homozygous mutant mice were viableExpand
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Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene.
  • K. Caron, O. Smithies
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 16 January 2001
Adrenomedullin, a recently identified potent vasodilator, is expressed widely and has been suggested to have functions ranging from reproduction to blood pressure regulation. To elucidate theseExpand
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Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.
  • O. Smithies
  • Biology, Medicine
  • The Biochemical journal
  • 1 December 1955
  • 702
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Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
A ‘rescuable’ plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled us to produce, score and clone mammalian cells with the plasmidExpand
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