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The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. Expand
Phylogenetic perspectives in innate immunity.
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity. Expand
Functional cDNA libraries from Drosophila embryos.
The design of the method and careful optimization of first strand synthesis have permitted cloning of several large cDNAs, and Transcription of essentially full-length clones with phage SP6 RNA polymerase produces RNAs that are efficiently translated in vitro to give complete, unfused products, thus permitting rapid characterization of the clones via the encoded polypeptides. Expand
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process. Expand
Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions, suggesting how innate immunity may have evolved. Expand
Immunity-Related Genes and Gene Families in Anopheles gambiae
242 Anopheles gambiae genes from 18 gene families implicated in innate immunity are identified and marked diversification relative to Drosophila melanogaster is detected, confirming that sequence diversification is accompanied by specific responses to different immune challenges. Expand
Complement-Like Protein TEP1 Is a Determinant of Vectorial Capacity in the Malaria Vector Anopheles gambiae
It is reported that the hemocyte-specific complement-like protein TEP1 from the mosquito Anopheles gambiae binds to and mediates killing of midgut stages of the rodent malaria parasite Plasmodium berghei. Expand
Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Aligned sequences reveal that orthologous genes have retained only half of their intron/exon structure, indicating that intron gains or losses have occurred at a rate of about one per gene per 125 million years, which indicates that these two insects diverged considerably faster than vertebrates. Expand
VectorBase: a data resource for invertebrate vector genomics
- D. Lawson, P. Arensburger, +24 authors F. Collins
- Computer Science, Biology
- Nucleic Acids Res.
- 21 November 2008
This report describes how VectorBase initiated a community annotation system, a microarray and gene expression repository and controlled vocabularies for anatomy and insecticide resistance, and continued to develop both the software infrastructure and tools for interrogating the stored data. Expand
Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes
Analysis of the interactions between Anopheles stephensi midgut epithelial cells and Plasmodium berghei ookinetes during invasion of the mosquito by the parasite indicates that the parasite inflicts extensive damage leading to subsequent death of the invaded cell. Expand