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The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.
Phylogenetic perspectives in innate immunity.
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
Functional cDNA libraries from Drosophila embryos.
Immunity-Related Genes and Gene Families in Anopheles gambiae
242 Anopheles gambiae genes from 18 gene families implicated in innate immunity are identified and marked diversification relative to Drosophila melanogaster is detected, confirming that sequence diversification is accompanied by specific responses to different immune challenges.
A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses
It is observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
Complement-Like Protein TEP1 Is a Determinant of Vectorial Capacity in the Malaria Vector Anopheles gambiae
Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions, suggesting how innate immunity may have evolved.
Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Aligned sequences reveal that orthologous genes have retained only half of their intron/exon structure, indicating that intron gains or losses have occurred at a rate of about one per gene per 125 million years, which indicates that these two insects diverged considerably faster than vertebrates.
Effects of Mosquito Genes on Plasmodium Development
It is shown by gene silencing that an Anopheles gambiae leucine rich-repeat protein acts as an antagonist and two C-type lectines act as protective agonists on the development of Plasmodium ookinetes to oocysts.
VectorBase: a data resource for invertebrate vector genomics
This report describes how VectorBase initiated a community annotation system, a microarray and gene expression repository and controlled vocabularies for anatomy and insecticide resistance, and continued to develop both the software infrastructure and tools for interrogating the stored data.