Hemoglobin Subunit Alpha

Known as: Alpha Globin, Alpha-Globin, Hemoglobin Alpha Chain 
Hemoglobin subunit alpha (142 aa, ~15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of… (More)
National Institutes of Health

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10 relations
Cellular MembraneErythrocytesHBA1 geneHBA2 gene
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin.
Adaptive modifications of heteromeric proteins may involve genetically based changes in single subunit polypeptides or parallel… (More)
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Highly Cited
2008
Highly Cited
2008
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment
Genes on different chromosomes can be spatially associated in the nucleus in several transcriptional and regulatory situations… (More)
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Highly Cited
2006
Highly Cited
2006
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.
We describe a pathogenetic mechanism underlying a variant form of the inherited blood disorder alpha thalassemia. Association… (More)
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Highly Cited
2000
Highly Cited
2000
Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin.
The stable introduction of a functional beta-globin gene in haematopoietic stem cells could be a powerful approach to treat beta… (More)
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Highly Cited
2000
Highly Cited
2000
Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions.
We describe a sensitive, reliable and reproducible method, based on three multiplex PCR assays, for the rapid detection of seven… (More)
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Highly Cited
1999
Highly Cited
1999
An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro.
The stable globin mRNAs provide an ideal system for studying the mechanism governing mammalian mRNA turnover. alpha-Globin mRNA… (More)
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Highly Cited
1997
Highly Cited
1997
G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection.
Splicing of small introns in lower eucaryotes can be distinguished from vertebrate splicing by the inability of such introns to… (More)
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Highly Cited
1995
Highly Cited
1995
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with α-thalassemia (ATR-X syndrome)
The ATR-X syndrome is an X-linked disorder comprising severe psychomotor retardation, characteristic facial features, genital… (More)
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Highly Cited
1990
Highly Cited
1990
The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model.
The CpG dinucleotide is present at approximately 20% of its expected frequency in vertebrate genomes, a deficiency thought due to… (More)
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Highly Cited
1983
Highly Cited
1983
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.
This paper describes a plasmid vector for cloning cDNAs in Escherichia coli; the same vector also promotes expression of the cDNA… (More)
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