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Initiation and termination of DNA replication in human rRNA genes
Termination of replication, the convergence of opposing replication forks, was found throughout the ribosomal DNA repeat units, and, in some repeats, specifically at the junction of the 3' end of the transcription unit and the NTS.
RNA processing generates the mature 3' end of yeast CYC1 messenger RNA in vitro.
The mature 3' ends of yeast mRNA's may be generated by endonucleolytic cleavage and polyadenylation rather than by transcription termination.
Maximizing gene expression from plasmid vectors containing the lambda PL promoter: strategies for overproducing transcription termination factor rho.
The results show that chemical induction of PL-containing plasmid expression vectors can serve as a convenient and useful alternative to the commonly used method of heat induction.
Transcription termination and the regulation of gene expression.
- T. Platt
- BiologyAnnual Review of Biochemistry
The Dynamics of Terminati on Mechanisms: Similarities and Diff erences shows how different types of sites have different mechanisms and how these mechanisms can be modified over time.
The complete nucleotide sequence of the tryptophan operon of Escherichia coli.
The complete nucleotide sequence for the five structural genes of the trp operon of E. coli together with the internal and flanking regions of regulatory information are presented.
Transcription termination factor rho is an RNA-DNA helicase
New features of the regulation of the tryptophan operon.
Rho and RNA: models for recognition and response
- T. Platt
- BiologyMolecular microbiology
- 1 March 1994
New insights are offered into the requirements for binding and ATPase activation by a variety of RNA substrates, dynamic analyses of Rho tracking, helicase and termination activity, and the participation of a new factor (NusG) that interacts with Rho.
Regulation of transcription from tandem and convergent promoters.
The strengths of the two promoters are comparable, though the lac UV5 promoter is much more sensitive to the level of initiating purine present than the trp promoter, and transcription eventually continues through.
Replicative intermediates of human papillomavirus type 11 in laryngeal papillomas: site of replication initiation and direction of replication.
- K. Auborn, R. D. Little, T. Platt, M. Vaccariello, C. Schildkraut
- BiologyProceedings of the National Academy of Sciences…
- 19 July 1994
The results demonstrate the feasibility of analysis of replication of viral genomes directly from infected tissue and show that replication forks proceed bidirectionally from the origin and converge 180 degrees opposite the URR.