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HGG 42

Known as: HGG-42, Pyridinium, 1-(((3-(cyclohexylcarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)-, diiodide 
National Institutes of Health

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Pyridinium Compounds

Papers overview

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2007
2007
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats
The oximes HI-6, HLö-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic… 
1986
1986
Bisquaternary Pyridinium Oximes as Presynaptic Agonists and Postsynaptic Antagonists of Muscarinic Receptors
Abstract: A study of the effects of bisquaternary pyridinium oximes on calcium‐dependent potassium‐evoked [3H]acetylcholine… 
1985
1985
Bisquaternary pyridinium oximes as allosteric inhibitors of rat brain muscarinic receptors.
The mode of interaction of bisquaternary pyridinium oximes with rat brain muscarinic receptors in cerebral cortex and brain stem… 
1985
1985
Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximes
The role of the functional substituents on the pyridinium ring of bisquaternary pyridinium compounds, mostly oximes, in exerting… 
Highly Cited
1984
Highly Cited
1984
Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of the nerve agent soman.
1984
1984
Isolation, in vitro activity, and acute toxicity in mice of the four stereoisomers of soman.
We report the isolation, on a 0.1- to 2-mg scale, of the four stereoisomers of the nerve agent pinacolyl… 
1983
1983
Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.
Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman… 
1981
1981
The treatment of Soman poisoning and its perspectives.
Soman is a highly toxic organophosphorus chemical warfare nerve agent which is characterized by (1) extremely rapid ageing of the… 
1980
1980
Reactivating and protective effects of pyridinium compounds in human erythrocyte acetylcholinesterase inhibition by organophosphates in vitro
The reactivation of human erythrocyte acetylcholinesterase (AChE, EC 3.1.1.7) inhibited by O-ethyl-S-2-di-isopropylaminoethyl… 
1979
1979
Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning… 
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