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Side effects of physostigmine as a pretreatment in guinea pigs
It is suggested that at relevant doses several PHY-induced phenomena occur that are unrelated to AChE inhibition, and not the effects of PNF, which was antagonized by scopolamine. Expand
Pharmacological effects of oximes: how relevant are they?
A new concept for further treatment is suggested: maintenance of neuronal transmission in spite of continued AChE-inhibition by pharmacological manipulation of the cholinergic receptor. Expand
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.
HI-6 is an effective treatment against soman poisoning in marmosets and AChE reactivation or protection by HI-6 contributed to the survival of the animals. Expand
Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses theExpand
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats
Results show that prolongation of survival time following lethal intoxication with an organophosphate can be achieved by non-reactivating properties of the oximes, and the observed differences in a) pharmacokinetics, b) potency to restore NMT and c) affinity for muscarinic receptors of the various oximes do not correlate with the observed Differences in therapeutic effectiveness. Expand
Irreversible binding of the chloropromazine radical cation and of photoactivated chlorpromazine to biological macromolecules.
The irreversible binding of chlorpromazine radical cation (CPZ+.) and photoactivated chlor Promazine ( CPZ) to calf thymus DNA in vitro and bacterial macromolecules in intact bacterium cells was investigated and the consequences of covalent binding for the cytotoxicity and genotoxicity of CPZ+. Expand
Toxicologic evaluation of pepper spray as a possible weapon for the Dutch police force: risk assessment and efficacy.
The efficacy and possible health risks of pepper spray were evaluated and it was concluded that the risk of long-term health effects is negligible. Expand
Effects of low doses of cholinesterase inhibitors on behavioral performance of robot-tested marmosets
Results strongly suggest that both soman and physostigmine may interfere with higher CNS functions at low dose levels, and these effects may go undetected because physical signs are absent. Expand
Subchronic Physostigmine Pretreatment in Guinea Pigs: Effective Against Soman and Without Side Effects
Subchronic application by osmotic minipumps of PHY, even without SCO, caused no behavioral or neurophysiological side effects and the treated animals were protected against a 3 x LD50 dose of soman. Expand
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation
It is concluded that in this case the NMT found was based on synaptic adaptation to the continued inhibition of ChE and that the survival of the animals might be due to a combination of this synaptic adaptation and central direct effects of HI-6. Expand