• Publications
  • Influence
Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune
The clinical course of experimental autoimmune encephalomyelitis in the present model was mainly chronic and progressive, but periods of incomplete remission did occur, and Quantification showed that the number of lesions in T2-weighted magnetic resonance images equalled those found by pathological examination, and thus T1-and-weighting magnetic resonance imaging can be used to discern the total lesion load. Expand
Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)
The value of EAE in marmoset monkeys as a model to assess the role of accessory molecules and cytokines in multiple sclerosis, and to evaluate targeted intervention, is demonstrated. Expand
Side effects of physostigmine as a pretreatment in guinea pigs
It is suggested that at relevant doses several PHY-induced phenomena occur that are unrelated to AChE inhibition, and not the effects of PNF, which was antagonized by scopolamine. Expand
Behavioral performance, brain histology, and EEG sequela after immediate combined atropine/diazepam treatment of soman-intoxicated rats
It is concluded that, in contrast with the LOW AS/DZ combination, HIGH AS/ DZ prevents active avoidance deficits, convulsions, and light-microscopically detectable neuropathology after soman intoxication, however, the results of EEG measurements suggest that some aberrations may still remain even after the HIGH AS-DZ treatment. Expand
Behavioral test systems in marmoset monkeys
The bungalow test, the hand-eye coordination test, and the fear-potentiated startle response are developed, which tests and quantifies pathological anxiety manifested by a response of fright. Expand
Pharmacological effects of oximes: how relevant are they?
A new concept for further treatment is suggested: maintenance of neuronal transmission in spite of continued AChE-inhibition by pharmacological manipulation of the cholinergic receptor. Expand
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.
HI-6 is an effective treatment against soman poisoning in marmosets and AChE reactivation or protection by HI-6 contributed to the survival of the animals. Expand
Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs
Only the pretreatment with PHY alone did not offer any protection against 2x LD50 soman intoxication, and the Pretreatment regime may perhaps further be improved by the addition of a nicotinic antagonist. Expand
Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses theExpand
Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour
The results confirmed the involvement of NMDA receptors in the maintenance of soman‐induced seizures and the development of brain damage and underline the current hypothesis that cholinergic mechanisms are responsible for eliciting seizure activity after soman. Expand