Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats

@article{Helden2007ComparisonOT,
  title={Comparison of the therapeutic effects and pharmacokinetics of HI-6, HL{\"o}-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats},
  author={H. Helden and H. J. Wiel and J. Zijlstra and B. Melchers and R. Busker},
  journal={Archives of Toxicology},
  year={2007},
  volume={68},
  pages={224-230}
}
The oximes HI-6, HLö-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic effects of oximes other than acetylcholinesterase (AChE) reactivation (so-called “nonreactivating effects”). To test this, anaesthetized, atropinized and artificially ventilated rats (n=8 or 16) were poisoned with a three times LD50 dose of the potent AChE-inhibitor crotylsarin (CRS, i.v.). CRS-inhibited rat AChE reactivation by the oximes. Five minutes after poisoning… Expand
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