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Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes.
Interleukin-8 (IL-8) is an important cytokine in inflammatory processes by functioning as a chemoattractant and as an activator of oxygen metabolism. In the present study we demonstrate that betaExpand
Organophosphate poisoning: a method to test therapeutic effects of oximes other than acetylcholinesterase reactivation in the rat.
A method was developed to study exclusively those therapeutic effects of oximes that are not related to reactivation of organophosphate-inhibited acetylcholinesterase (AChE). The model uses theExpand
Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats
Results show that prolongation of survival time following lethal intoxication with an organophosphate can be achieved by non-reactivating properties of the oximes, and the observed differences in a) pharmacokinetics, b) potency to restore NMT and c) affinity for muscarinic receptors of the various oximes do not correlate with the observed Differences in therapeutic effectiveness. Expand
The in vitro effect of a thymic epithelial culture supernatant on mixed lymphocyte reactivity and intracellular cAMP levels of thymocytes and on antibody production to SRBC by Nu/Nu spleen cells.
If TES is added together withThymocytes to T-cell-deprived spleen cell cultures, the number of plaque-forming cells to SRBC is enhanced, suggesting that TES induces a helper cell function in thymocytes which, if added alone, have no effect. Expand
Increase in T cell mitogen responsiveness in rat thymocytes by thymic epithelial culture supernatant
It was demonstrated that the increased mitogen responsiveness was at least partially due to an increase in the number of responsive cells, and it was suggested that the target cell for TES resides among the cortisone‐sensitive population of thymocytes. Expand
A jungle full of pitfalls.
It is the inflexibility of Italian academic institutions that has the greatest effect on their scientific interactions with industry, and the situation may be different in the near future. Expand
Distinct role of neonatal and adult monocytes in the regulation of the in vitro antigen-induced plaque-forming cell response in man.
It was concluded that neonatal and adult AC differ in their antigen handling capacity and the presence of the prostaglandin synthetase inhibitor indomethacin affects the interaction between antigen and monocytes. Expand
Modulation of Lymphocyte Function by Endorphins
It is demonstrated that &endorphin can interfere with the process of proliferation of human lymphocytes either in a positive or in a negative way and the response of the lymphocytes to the amino acid fragment 1016 determines the outcome of the response. Expand
Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells
The data suggest that the primary target of GC in neonatal cells is inhibition of IL‐2 production, whereas in adult cells, other mechanisms are responsible for inhibition of T cell proliferation. Expand