Skip to search formSkip to main contentSkip to account menu

HER-2/neu intracellular domain protein

Known as: HER-2 ICD Peptide, HER2 Intracellular Domain, HER2 ICD 
The cytoplasmic domain or intracellular domain (ICD) of the HER2/neu protein that exhibits tyrosine kinase activity. Based on sensitization theory… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

erbB-2 Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Shed HER2 surrogacy evaluation in primary breast cancer patients: a study assessing tumor tissue HER2 expression at both extracellular and intracellular levels
Abstract The aim of the present study was to investigate serum HER2 extracellular domain (ECD) as a putative surrogate marker of… 
2017
2017
Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance
2016
2016
Abstract P2-11-03: Phase I/II randomized study of combination immunotherapy with or without polysaccharide krestin (PSK) concurrently with a HER2 ICD peptide-based vaccine in patients with stage IV…
Natural killer (NK) cell defects, commonly seen in metastatic breast cancer (MBC) lead to decrease in dendritic cell (DC… 
2016
2016
Abstract P3-07-06: Objective measurement of HER2 (ERBB2) intracellular and extracellular domain spatial co-localization stratifies benefit from adjuvant trastuzumab
Background: The ASCO/CAP guidelines consider chromogen-based immunohistochemistry (IHC) as the primary assay to determine HER2… 
2014
2014
A phase I trial of the safety and immunogenicity of a DNA-based vaccine encoding the HER2/neu (HER2) intracellular domain in subjects with HER2+ breast cancer.
616 Background: Vaccination with the intracellular domain (ICD) of HER2 in pre-clinical models is both immunogenic and protective… 
2009
2009
Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab. Phase 2
Abstract : The primary purpose of this grant is to determine the relapse free survival benefit with locally advanced and stage IV… 
2004
2004
악성 근골격계 종양세서 CD117[c-kit]과 Her-2/neu 유전자 발현
목적: 본 연구는 악성 근골격계 종양에서 c-kit (CD117) 유전자 단백질 발현과 Her-2/neu… 
Highly Cited
2002
Highly Cited
2002
Identification of a Region within the ErbB2/HER2 Intracellular Domain That Is Necessary for Ligand-independent Association*
Ligand-independent ErbB2 activation occurs principally by two distinct mechanisms: overexpression and mutation. Overexpression of… 
2000
2000
Sentinel-Lymphknotenbiopsie — Freie Themen
noklonalen (Ab-2 und Ab-3. Oncogene: CBll . Novocastra: TAB 250, Zymed; HER-2/neu. GSF Mdnchen) und 2 polyklonalen (A 8010, Oncor… 
Highly Cited
1992
Highly Cited
1992
Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells.
The HER-2/neu protooncogene (also called erbB-2) encodes a tyrosine kinase receptor for a polypeptide growth-regulatory molecule… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)