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Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition
TLDR
The genomes of uterine and ovarian CSs demonstrated that these different cell types derive from a common precursor cell that has many mutations typical of epithelial cancers, and expression of specific histone gene mutations in uterine carcinoma cells changed gene expression toward a mesenchymal state. Expand
Immunotherapy and targeted therapy for cervical cancer: an update
TLDR
Background information on the molecular biology of cervical cancer is provided and immunotherapy studies, targeted therapies, including those with angiogenesis inhibitors and tyrosine kinase inhibitors recently completed or currently on-going in cervical cancer patients are summarized. Expand
A Series of Malignant Ovarian Cancers Arising From Within a Mature Cystic Teratoma: A Single Institution Experience
TLDR
A large ovarian mass that is suspected to be a mature teratoma should be managed more aggressively in older patients, more likely when patients are older than 40 years, the mass is greater than 18 cm, and there is any suspicion for a mucinous tumor. Expand
Management of sexuality, intimacy, and menopause symptoms in patients with ovarian cancer
TLDR
At the time of diagnosis or at initial consultation, women should be informed of the potential physiologic, hormonal, and psychosocial effects of ovarian cancer on sexuality and that there is a multimodal approach to dealing with symptoms. Expand
Robotic Versus Laparoscopic Hysterectomy for Benign Disease: A Systematic Review and Meta-Analysis of Randomized Trials.
TLDR
Current evidence demonstrates neither statistically significant nor clinically meaningful differences in surgical outcomes between robotic and laparoscopic hysterectomy for benign disease. Expand
PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas
TLDR
Oncogenic PIK3CA mutations are common in HER2/neu-amplified USC and may constitute a major mechanism of resistance to trastuzumab treatment. Expand
SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression.
TLDR
SYD985 is a novel ADC with remarkable activity against EOC with strong (3+) as well as moderate to low (i.e., 2+ and 1+) Her2/neu expression and unlike T-DM1, it is active against Eoc demonstrating moderate/low or heterogeneous HER2/NEu expression. Expand
Surgical Site Infections in Gynecology
TLDR
A thorough review of the most up-to-date peer-reviewed articles and review articles as well as guidelines and recommendations of various professional organizations including the US Centers for Disease Control and Prevention and the American College of Obstetrics and Gynecology to better understand the prevention, diagnosis, and management of surgical site infections. Expand
An unexpected mass of the urachus: a case report.
TLDR
This case reveals the feasibility of a minimally invasive abdominal wall mass resection and illustrates the importance of preoperative identification of urachal and bladder neoplasms. Expand
Uterine Didelphys and Vaginal Birth After Cesarean Delivery
TLDR
There is sparse literature on a trial of labor after cesarean delivery in a uterine didelphys, and a 30-year-old woman, gravida 2 para 1001, presented in latent labor at 40 1/7 weeks of gestation. Expand
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