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HCRT protein, human

Known as: Preproorexin, Prepro-Orexin, Hcrt 
Orexin (131 aa, ~13 kDa) is encoded by the human HCRT gene. This protein is involved in neuropeptide-dependent signaling and feeding behavior.
National Institutes of Health

Related topics

Related topics

7 relations
Desire for foodExtracellular SpaceG Protein-Coupled Receptor SignalingHCRT gene

Broader (1)

orexins

Papers overview

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Review
2010
Review
2010
Hypocretin/orexin in arousal and stress
Highly Cited
2008
Highly Cited
2008
Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
The hypocretin/orexin (HCRT) neuropeptide system modulates behavioral state and state‐dependent processes via actions on multiple… 
Highly Cited
2007
Highly Cited
2007
A Role for Hypocretin (Orexin) in Male Sexual Behavior
The role of hypocretin (orexin; hcrt/orx) neurons in regulation of arousal is well established. Recently, hcrt/orx has been… 
Highly Cited
2006
Highly Cited
2006
Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area
Hypocretins (HCRTs) modulate a variety of behavioral and physiological processes, in part via interactions with multiple… 
Highly Cited
2006
Highly Cited
2006
Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal.
The paraventricular thalamic nucleus (PVT) receives one of the most dense innervations by hypothalamic hypocretin/orexin (Hcrt… 
Highly Cited
2005
Highly Cited
2005
Orexin loss in Huntington's disease.
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding… 
Review
2004
Review
2004
Hypocretin (orexin): role in normal behavior and neuropathology.
The hypocretins (Hcrts, also known as orexins) are two peptides, both synthesized by a small group of neurons, most of which are… 
Highly Cited
2004
Highly Cited
2004
Exclusive Postsynaptic Action of Hypocretin-Orexin on Sublayer 6b Cortical Neurons
The hypocretin-orexin (hcrt-orx) neurons are thought to maintain wakefulness because their loss results in narcolepsy. This role… 
Highly Cited
2003
Highly Cited
2003
Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration
Highly Cited
2001
Highly Cited
2001
Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
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