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HCK gene

Known as: HCK, HEMOPOIETIC CELL KINASE, HCK proto-oncogene, Src family tyrosine kinase 
This gene plays a role in the regulation of myeloid cell signaling.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell ProliferationHCK protein, humanHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.
2015
2015
Involvement of the HCK and FGR src-Family Kinases in FCRL4-Mediated Immune Regulation
FCRL4 is an immunoregulatory receptor expressed by a subpopulation of memory B cells. These tissue-based cells express increased… 
2015
2015
Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells.
Chronic exposure to trichothecenes is known to disturb insulin-like growth factor 1 and signaling of insulin and leptin hormones… 
2013
2013
Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors
Recombinant immunotoxins (RIT) are agents being developed for cancer treatment. They are composed of an Fv that binds to a cancer… 
2013
2013
Prolactin-Induced Protein (PIP) Regulates Proliferation of Luminal A Type Breast Cancer Cells in an Estrogen-Independent Manner
Prolactin-induced Protein (PIP), an aspartyl protease unessential for normal mammalian cell function, is required for the… 
2012
2012
Tyrosine kinase expression profile in clear cell renal cell carcinoma
PurposeTo profile different tyrosine kinase (TK) expression patterns in clear cell renal carcinoma (ccRCC).MethodsWe analysed… 
2009
2009
GNF-2, An Allosteric BCR-ABL Inhibitor, Identifies a Novel Myristoylation-Mediated Mechanism Regulating the Ability of BCR-ABL to Activate HCK and IGF-1 Signaling.
Abstract 40 Pharmacologic inhibition of BCR-ABL, using clinically active ATP-competitive inhibitors imatinib, nilotinib, and… 
Highly Cited
2007
Highly Cited
2007
CD66b Regulates Adhesion and Activation of Human Eosinophils1
Eosinophils and their products are likely important in the pathophysiology of allergic diseases, such as bronchial asthma, and in… 
1998
1998
Nef proteins of distinct HIV-1 or -2 isolates differ in their binding properties for HCK: isolation of a novel Nef binding factor with characteristics of an adaptor protein.
The Nef gene of the human and simian immunodeficiency viruses HIV and SIV has been implicated in pathogenicity; however, the… 
1992
1992
Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region.
The vertebrate gene HCK encodes a protein-tyrosine kinase that is closely related to the product of the proto-oncogene SRC. HCK… 
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