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HCK protein, human

Known as: hemopoietic cell kinase protein, human, p61Hck, Hematopoietic Cell Kinase 
Tyrosine-protein kinase Hck (526 aa, ~60 kDa) is encoded by the human HCK gene. This protein plays a role in tyrosine phosphorylation, signaling and… 
National Institutes of Health

Related topics

Related topics

21 relations
B-LymphocytesCell Differentiation processCell ProliferationEnzyme Gene

Broader (2)

Protein Tyrosine KinaseProto-Oncogene Proteins c-hck

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms.
2007
2007
Activation of p61Hck Triggers WASp- and Arp2/3-dependent Actin-comet Tail Biogenesis and Accelerates Lysosomes*
Secretory lysosomes exist in few cell types, but various mechanisms are involved to ensure their mobilization within the… 
2005
2005
The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into vif-defective HIV-1 particles.
Highly Cited
2003
Highly Cited
2003
CSF-induced and HIV-1–mediated Distinct Regulation of Hck and C/EBPβ Represent a Heterogeneous Susceptibility of Monocyte-derived Macrophages to M-tropic HIV-1 Infection
Granulocyte/macrophage colony-stimulating factor (GM-CSF)–induced monocyte-derived macrophages (GM-MΦ) are permissive to M-tropic… 
2003
2003
Critical role for Hck-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin-6-induced proliferation and survival of multiple myeloma cells.
2000
2000
Lipoarabinomannans Activate the Protein Tyrosine Kinase Hck in Human Neutrophils
ABSTRACT The mycobacterial lipoarabinomannans (LAMs) are glycosylphosphatidyl-myo-inositol-anchored lipoglycans with diverse… 
Highly Cited
1997
Highly Cited
1997
Bacterial LPS and IFN‐γ trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase
We and others have previously reported that tyrosine kinases play key roles in the activation of macrophages by both bacterial… 
1997
1997
Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes*
Regulation of neutrophil responses is known to involve tyrosine phosphorylation. Hck, a major neutrophil protein-tyrosine kinase… 
1992
1992
Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region.
The vertebrate gene HCK encodes a protein-tyrosine kinase that is closely related to the product of the proto-oncogene SRC. HCK… 
1989
1989
Transformation of NIH 3T3 fibroblasts by an activated form of p59hck
Phosphorylation of a tyrosine residue near the carboxy terminus of src-family protein tyrosine kinases is believed to regulate… 
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