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HBB wt Allele

Known as: CD113t-C, Hemoglobin Beta wt Allele, beta-globin 
Human HBB wt allele is located in the vicinity of 11p15.5 and is approximately 4 kb in length. This allele, which encodes hemoglobin subunit beta… 
National Institutes of Health

Related topics

Related topics

11 relations
11p15.5Anemia, Sickle CellCell RespirationHemoglobin C Disease

Broader (1)

HBB gene

Papers overview

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Highly Cited
2001
Highly Cited
2001
Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCR.
We employ real-time PCR to allow us to quantify the sensitivity of chromatin to digestion by DNaseI. This approach has three… 
Highly Cited
1999
Highly Cited
1999
Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription
ABSTRACT The human β-globin locus control region (LCR) harbors both strong chromatin opening and enhancer activity when assayed… 
Highly Cited
1996
Highly Cited
1996
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome…
To analyze the function of the 5' DNase I hypersensitive sites (HSs) of the locus control region (LCR) on beta-like globin gene… 
Highly Cited
1989
Highly Cited
1989
The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.
We linked a 3.3-kilobase fragment containing the entire A gamma-globin gene together with 1.3 kilobases of 5' flanking and 0.37… 
Highly Cited
1985
Highly Cited
1985
The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein.
A component present in splicing extracts selectively binds the 3' splice site of a precursor messenger RNA (pre-mRNA) transcript… 
Highly Cited
1985
Highly Cited
1985
Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.
We describe five individuals who have constitutional deletions of the short arm of one chromosome 11, including all or part of… 
Highly Cited
1984
Highly Cited
1984
Dispersal process associated with the L1 family of interspersed repetitive DNA sequences.
Highly Cited
1983
Highly Cited
1983
cis and trans activation of globin gene transcription in transient assays.
We examined the effects of the simian virus 40 enhancer sequence on transcription of cloned human alpha- and beta-globin genes… 
Highly Cited
1981
Highly Cited
1981
A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs.
The hemoglobin beta-1 gene of the rabbit was linked to a 244 bp DNA fragment from the beginning of the polyoma virus late region… 
Highly Cited
1981
Highly Cited
1981
Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA.
A nonadecanucleotide has been used both as a site specific mutagen to introduce a T leads to A transversion mutation in the human… 
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