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HuR and mRNA stability
Abstract. An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3′Expand
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Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
AU-rich elements (AREs) and microRNA target sites are conserved sequences in messenger RNA (mRNA) 3′ untranslated regions (3′UTRs) that control gene expression posttranscriptionally. Upon cell cycleExpand
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Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon
Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are discriminated from true termination codons by downstream cis-elements, such asExpand
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Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.
Mice of the strain MRL/Mp-lpr/lpr develop a lupus erythematosus-like syndrome that includes the production of autoantibodies specific for nucleic acid-containing cellular components. We have fusedExpand
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SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.
The only mammalian RNA binding adapter proteins known to partner with TAP/NXF1, the primary receptor for general mRNA export, are members of the REF family. We demonstrate that at least threeExpand
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Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated regions (UTRs). HuR, aExpand
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Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
In animals, microRNAs (miRNAs) bind to the 3′ UTRs of their target mRNAs and interfere with translation, although the exact mechanism of inhibition of protein synthesis remains unclear. FunctionalExpand
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Identification of a sex-factor-affinity site in E. coli as gamma delta.
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A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles.
Small Cajal body (CB)-specific RNPs (scaRNPs) function in posttranscriptional modification of small nuclear (sn)RNAs. An RNA element, the CAB box, facilitates CB localization of H/ACA scaRNPs. UsingExpand
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HNS, a nuclear-cytoplasmic shuttling sequence in HuR.
  • X. C. Fan, J. Steitz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 22 December 1998
Proteins are transported into and out of the cell nucleus via specific signals. The two best-studied nuclear transport processes are mediated either by classical nuclear localization signals orExpand
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