The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

@article{Enver1989TheHB,
  title={The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.},
  author={Tariq Enver and Allen J. Ebens and William C. Forrester and G. Stamatoyannopoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 18},
  pages={
          7033-7
        }
}
We linked a 3.3-kilobase fragment containing the entire A gamma-globin gene together with 1.3 kilobases of 5' flanking and 0.37 kilobase of 3' flanking DNA to a 2.5-kilobase fragment containing four of the developmentally stable hypersensitive sites normally located in the 5' region of the human beta-globin locus. This construct was injected into fertilized mouse eggs, and its expression was analyzed in the primitive and definitive erythroid cells, as well as the brain of 14-day embryos. All… CONTINUE READING

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