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Guanethidine

Known as: Oktadin, (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine, guanéthidine 
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by… 
National Institutes of Health

Related topics

Related topics

27 relations

Broader (6)

Adrenergic AgentsAminesAntihypertensive AgentsGuanidine
Adrenergic alpha2-Agonists [MoA]Congestive heart failureDecreased Blood Pressure [PE]Guanethidine Sulfate

Narrower (6)

EsimilGuanethidine MonosulfateIsmelinIsobarin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Blood volume and exchangeable sodium during treatment of hypertension with guanethidine and hydrochlorothiazide.
Antipressor treatment with guanethidine for 8 to 14 days produce a significant average increase in blood volume and exchangeable… 
1982
1982
Impairment of trophic response of brown fat to cold in guanethidine-treated rats.
The aim of the present study was to investigate the role of the sympathetic nervous system in the trophic response of brown… 
1973
1973
Guanethidine and adrenaline used in combination in chronic simple glaucoma.
Guanethidine is effective in the control ofintraocular pressure (IOP) in some patients with chronic simple glaucoma. Stepanik and… 
1971
1971
Antihypertensive effect of clonidine. Its use alone and in combination with hydrochlorothiazide and guanethidine in the treatment of hypertension.
A new antihypertensive agent, clonidine hydrochloride, was administered to 27 patients with essential hypertension for periods… 
Highly Cited
1971
Highly Cited
1971
The reflex stimulation of catecholamine secretion during the acute stage of myocardial infarction in the dog.
1. The mechanism of catecholamine secretion after coronary occlusion was investigated in open-chest, anaesthetized dogs; the… 
1968
1968
Thyroxine deiodination during cold exposure in the rat
1. The urinary radio‐iodide excretion following injection of [131I]thyroxine and tri‐iodothyronine is increased in acutely cold… 
Highly Cited
1965
Highly Cited
1965
The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents.
A SIGNIFICANT advance in the treatment of moderate to malignant hypertension has been the development of potent agents that… 
1963
1963
POTENTIATION OF SOME CATECHOL AMINES BY PHENOXYBENZAMINE, GUANETHIDINE AND COCAINE.
In rabbit isolated atria, cocaine, guanethidine and phenoxybenzamine increased the changes in rate and force of contractions… 
1962
1962
Comparison of bretylium and guanethidine: tolerance, and effects on adrenergic nerve function and responses to sympathomimetic amines.
Bretylium depresses the slope of regression lines relating frequency of sympathetic nerve stimulation to magnitude of… 
1962
1962
Guanethidine in the Treatment of Hypertension
IN the last decade great advances have been made in the treatment of hypertension, so that it is now possible in most cases, by…