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Guanethidine

Known as: Oktadin, (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine, guanéthidine 
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by… 
National Institutes of Health

Related topics

Related topics

27 relations

Broader (6)

Adrenergic AgentsAminesAntihypertensive AgentsGuanidine
Adrenergic alpha2-Agonists [MoA]Congestive heart failureDecreased Blood Pressure [PE]Guanethidine Sulfate

Narrower (6)

EsimilGuanethidine MonosulfateIsmelinIsobarin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
Role of sympathoadrenomedullary system in cardiovascular response to stress in rats.
Highly Cited
1984
Highly Cited
1984
Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests
Highly Cited
1982
Highly Cited
1982
The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum
1. The nature of the non‐cholinergic, non‐adrenergic (non‐ch., non‐adr.) excitatory and inhibitory transmission in the… 
Highly Cited
1980
Highly Cited
1980
Evidence for vagal enkephalinergic neural control of the feline pylorus and stomach
Highly Cited
1979
Highly Cited
1979
Iris Adrenergic Impairment in Idiopathic Headache
SYNOPSIS 
Highly Cited
1979
Highly Cited
1979
Actions of somatostatin on excitatory and inhibitory nerves in the intestine.
Highly Cited
1975
Highly Cited
1975
Factors influencing transmission at adrenergic synapses
Highly Cited
1966
Highly Cited
1966
Studies in vitro of amine uptake mechanisms in heart.
Highly Cited
1966
Highly Cited
1966
Transmission from perivascular inhibitory nerves to the smooth muscle of the guinea‐pig taenia coli
1. Membrane potential changes of the smooth muscle cells of the taenia coli were recorded during stimulation of the perivascular… 
Highly Cited
1959
Highly Cited
1959
A new, potent antihypertensive drug: preliminary study of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (guanethidine).
The antihypertensive effects of orally given guanethidine have been studied in 18 patients hospitalized for hypertensive… 
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