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Guanethidine

Known as: Oktadin, (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine, guanéthidine 
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by… 
National Institutes of Health

Related topics

Related topics

27 relations

Broader (6)

Adrenergic AgentsAminesAntihypertensive AgentsGuanidine
Adrenergic alpha2-Agonists [MoA]Congestive heart failureDecreased Blood Pressure [PE]Guanethidine Sulfate

Narrower (6)

EsimilGuanethidine MonosulfateIsmelinIsobarin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Blood volume and exchangeable sodium during treatment of hypertension with guanethidine and hydrochlorothiazide.
Antipressor treatment with guanethidine for 8 to 14 days produce a significant average increase in blood volume and exchangeable… 
1986
1986
Liquid chromatographic determination of guanethidine salts and hydrochlorothiazide using electrochemical detection and ion-pair techniques.
A high-performance liquid chromatographic method with amperometric detection utilizing oxidation at the glassy carbon electrode… 
1982
1982
Impairment of trophic response of brown fat to cold in guanethidine-treated rats.
The aim of the present study was to investigate the role of the sympathetic nervous system in the trophic response of brown… 
1979
1979
The combination of guanethidine 3% and adrenaline 0.5% in 1 eyedrop (GA) in glaucoma treatment.
During a 7-month period 33 patients (20 with primary open-angle glaucoma and 13 with suspected glaucoma) were treated with… 
Highly Cited
1975
Highly Cited
1975
The diagnosis and treatment of Raynaud's phenomenon.
Twenty-five patients with Raynaud's phenomenon, including 20 with associated diseases and five with primary Raynaud's disease… 
1972
1972
Growth inhibition of sympathetic cells by some adrenergic blocking agents (6-hydroxydopamine-mice and rats-immunosympathectomy-chemical sympathectomy-superior cervical ganglion).
Treatment of newborn mice and rats with the adrenergic blocking agents, guanethidine and bretylium tosylate, results in massive… 
Highly Cited
1971
Highly Cited
1971
The reflex stimulation of catecholamine secretion during the acute stage of myocardial infarction in the dog.
1. The mechanism of catecholamine secretion after coronary occlusion was investigated in open-chest, anaesthetized dogs; the… 
1962
1962
Guanethidine (Ismelin) in ophthalmology. I. Observations in rabbits.
Introduction Guanethidine (Ismelin*) is a substance which reduces the activity of the sympathetic nervous system (Maxwell et al… 
1962
1962
Guanethidine as an Antipruritic: Special Reference to Atopic Dermatitis
The antipruritic action of guanethidine has not been related up till now to its sympathicoplegic properties. We have studied its… 
1961
1961
Acute hemodynamic responses to intravenous and intra-arterial guanethidine.
Intravenous administration of guanethidine to dogs causes an abrupt fall in systemic arterial pressure which is followed by a…