Granulocyte differentiation

Known as: Granulopoiesis, granulocyte cell differentiation 
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes… (More)
National Institutes of Health

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Blood CellsBone MarrowCBFA2T3 geneCBFA2T3 protein, human
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Highly Cited
2013
Highly Cited
2013
Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to failed excision of intronic sequences… (More)
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Highly Cited
2007
Highly Cited
2007
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
Monocyte differentiation involves the participation of lineage-restricted transcription factors, although the mechanisms by which… (More)
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Highly Cited
2005
Highly Cited
2005
A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis
MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of specific target genes. Here we… (More)
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Highly Cited
2004
Highly Cited
2004
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.
The regulation of cell mass (cell growth) is often tightly coupled to the cell division cycle (cell proliferation). Ribosome… (More)
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Highly Cited
2003
Highly Cited
2003
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using… (More)
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Highly Cited
2001
Highly Cited
2001
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
Bacterial pneumonia is an increasing complication of HIV infection and inversely correlates with the CD4(+) lymphocyte count… (More)
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Highly Cited
1996
Highly Cited
1996
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice.
We have generated mice carrying a homozygous null mutation in the granulocyte colony-stimulating factor receptor (G-CSFR) gene. G… (More)
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Highly Cited
1994
Highly Cited
1994
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.
Mice lacking granulocyte colony-stimulating factor (G-CSF) were generated by targeted disruption of the G-CSF gene in embryonal… (More)
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Highly Cited
1993
Highly Cited
1993
Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.
Growth factor-induced signals govern the expression of three D-type cyclins, which, in turn, function as regulatory subunits of… (More)
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Highly Cited
1970
Highly Cited
1970
In vitro induction of granulocyte differentiation in hematopoietic cells from leukemic and non-leukemic patients.
Human spleen-conditioned medium can induce the formation in vitro of large granulocyte colonies from normal human bone marrow… (More)
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