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The nature of the principal type 1 interferon-producing cells in human blood.
Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge and are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses. Expand
Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions.
Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured, and were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro. Expand
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation.
HIV-1-infected DCs have two previously unrecognized means to evade immune responses: maturation can be blocked reducing the efficacy of antigen presentation from infected cells, and T cell-dependent suppression can be induced. Expand
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes
The results, based on humans with highly polymorphic MHC products, reveal that DCs and DEC-205 can cross-present several different peptides from a single protein, which support the testing of αDEC-205 fusion mAb as a protein-based vaccine. Expand
Circulating, Interferon‐Producing Plasmacytoid Dendritic Cells Decline During Human Ageing
Significant decreases of the circulating pDCs during ageing in healthy adult humans are found, as defined both by flow cytometry and IFN‐α generation. Expand
Dendritic Cell Numbers in the Blood of HIV-1 Infected Patients Before and After Changes in Antiretroviral Therapy
Antigen presenting dendritic cells (DCs) can serve as sites for HIV replication and as vehicles for transmission of the virus to T cells. It is known that the numbers of DCs in blood is reducedExpand
Evidence of dysregulation of dendritic cells in primary HIV infection.
It is found that both myeloid DC and plasmacytoid DC levels decline very early during acute HIV infection, which implicates a possible role for DCs in promoting chronic immune activation. Expand
Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen.
In prior studies a heteroantiserum to a surface membrane component termed T(H2) was used to define two subsets of human T cells (T(H2) (+) and T(H2) (-)), which were found to express distinct sets ofExpand
Opportunistic infection in previously healthy women. Initial manifestations of a community-acquired cellular immunodeficiency.
Five women living in metropolitan New York City closely associated with drug abuse either by personal use or close sexual contact with an abuser with the same syndrome are reported, one of which is bisexual. Expand
Frequency of and outcome of acute coronary syndromes in patients with human immunodeficiency virus infection.
Fifty-one patients with human immunodeficiency virus infection and acute coronary syndromes were identified. Nearly all patients (98%) had traditional coronary risk factors. RevascularizationExpand