Gliotoxin

Known as: Gliotoxins, (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione, 10H-3,10a-Epidithiopyrazino(1,2-a)indole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl- 
A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Gliotoxin, and other related molecules, are encoded by multi-gene clusters and biosynthesized by fungi using non-ribosomal… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Gliotoxin is a epipolythiodioxopiperazine toxin that is made by the filamentous fungus Aspergillus fumigatus… (More)
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Highly Cited
2007
Highly Cited
2007
Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent… (More)
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Highly Cited
2005
Highly Cited
2005
Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with… (More)
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Highly Cited
2005
Highly Cited
2005
Aspergillus fumigatus (AF) is a ubiquitous mold and is the most common cause of invasive aspergillosis, an important source of… (More)
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Highly Cited
2004
Highly Cited
2004
Aspergillus fumigatus is a pathogenic fungus capable of causing both allergic lung disease and invasive aspergillosis, a serious… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND & AIMS Hepatic stellate cells (HSCs) play a pivotal role in liver fibrosis and stimulating their apoptosis could be an… (More)
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Highly Cited
1999
Highly Cited
1999
Age is one of the many factors that influence remyelination following CNS demyelination, although it is not clear whether it is… (More)
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Highly Cited
1996
Highly Cited
1996
Opportunistic infections, such as aspergillosis, are among the most serious complications suffered by immunocompromised patients… (More)
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Review
1996
Review
1996
1. Gliotoxin belongs to the epipolythiodioxopiperazine class of secondary metabolites. These compounds show a diverse range of… (More)
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