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Gliotoxin

Known as: Gliotoxins, (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione, 10H-3,10a-Epidithiopyrazino(1,2-a)indole-1,4-dione, 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl- 
A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (1)

Immunosuppressive Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (6)

KT 7595bisdethiobis(methylthio)gliotoxindehydrogliotoxindehydroxybisdethiobis(methylthio)gliotoxin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans.
Highly Cited
2005
Highly Cited
2005
The ABC transporter gene in the sirodesmin biosynthetic gene cluster of Leptosphaeria maculans is not essential for sirodesmin production but facilitates self-protection.
Highly Cited
1997
Highly Cited
1997
Apoptosis Induced by Gliotoxin Is Preceded by Phosphorylation of Histone H3 and Enhanced Sensitivity of Chromatin to Nuclease Digestion*
The fungal toxin gliotoxin induces apoptotic cell death in a variety of cells. Apoptosis induced in thymocytes by gliotoxin is… 
Highly Cited
1994
Highly Cited
1994
Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor
Highly Cited
1992
Highly Cited
1992
Gliotoxic actions of excitatory amino acids
Highly Cited
1988
Highly Cited
1988
Mechanism of gliotoxin action and factors mediating gliotoxin sensitivity
Summary: Resistance to the low M r fungal epipolythiodiketopiperazine toxin, gliotoxin, varied threefold between the… 
Highly Cited
1986
Highly Cited
1986
Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity.
Highly Cited
1984
Highly Cited
1984
Immunosuppression in vitro by a metabolite of a human pathogenic fungus.
Gliotoxin , a metabolite of Aspergillus fumigatus, inhibits phagocytosis of macrophages at concentrations of 20-50 ng/ml… 
1968
1968
Serologic tests in diagnosis of aspergillosis.
SUMMARY The complement fixation test was found to be both sensitive and specific for detecting antibodies to Aspergillus… 
Highly Cited
1964
Highly Cited
1964
Antiviral Activity of Gliotoxin and Gliotoxin Acetate
DURING a search for antiviral materials, we found several Penicillium culture filtrates that inhibited the cytopathic effect of… 
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