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LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
A novel Aspergillus nuclear protein, LaeA, is presented here as a global regulator of secondary metabolism in this genus, and strains show little difference in spore production compared to the wild type, indicating that the primary role of laeA is to regulate metabolic gene clusters. Expand
Fungal secondary metabolism — from biochemistry to genomics
Questions are addressed, including which evolutionary pressures led to gene clustering, why closely related species produce different profiles of secondary metabolites, and whether fungal genomics will accelerate the discovery of new pharmacologically active natural products. Expand
VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism
This work has identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism in Aspergillus nidulans, which inhibits sexual reproduction as well as secondary metabolism. Expand
Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
An overview of the significant findings regarding A. fumigatus pathogenesis as it pertains to invasive disease is provided. Expand
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. Expand
Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans.
Genetic evidence is provided that the FlbA/FadA signaling pathway regulating ST production and morphological development is partially mediated through PkaA, a potential downstream target of FadA activity. Expand
Relationship between Secondary Metabolism and Fungal Development
- A. M. Calvo, Richard A. Wilson, J. Bok, N. Keller
- Medicine, Biology
- Microbiology and Molecular Biology Reviews
- 1 September 2002
In the case of the filamentous fungus Aspergillus nidulans, the only described work that genetically links the sporulation of this fungus to the production of the mycotoxin sterigmatocystin through a shared G-protein signaling pathway is reviewed. Expand
Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.
- D. Brown, J. H. Yu, +5 authors T. Leonard
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 20 February 1996
A 60-kb region in the A. nidulans genome is characterized and it is found it contains many, if not all, of the genes needed for ST biosynthesis. Expand
Oxylipins as developmental and host-fungal communication signals.
Results suggest that host and microbial oxylipins might interfere with the metabolism, perception or signalling processes of each other. Expand
Transcriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
It is suggested that Aspergillus fumigatus secondary metabolite gene clusters constitute evolutionarily diverse regions that may be important for niche adaptation and virulence attributes and that LaeA is a novel target for comprehensive modification of chemical diversity and pathogenicity. Expand