Genomic Analysis of the Necrotrophic Fungal Pathogens Sclerotinia sclerotiorum and Botrytis cinerea
- J. Amselem, C. Cuomo, M. Dickman
- BiologyPLoS Genetics
- 1 August 2011
Comparative genome analysis revealed the basis of differing sexual mating compatibility systems between S. sclerotiorum and B. cinerea, and shed light on the evolutionary and mechanistic bases of the genetically complex traits of necrotrophic pathogenicity and sexual mating.
Molecular cloning of a putative receptor protein kinase gene encoded at the self-incompatibility locus of Brassica oleracea.
- J. Stein, B. Howlett, D. Boyes, M. Nasrallah, J. Nasrallah
- BiologyProceedings of the National Academy of Sciences…
- 1 October 1991
The S receptor kinase (SRK) gene is described, a previously uncharacterized gene that resides at the S locus that exhibits striking homology to the secreted product of the S-locus glycoprotein (SLG) gene.
The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis.
- D. Gardiner, P. Waring, B. Howlett
- 1 April 2005
With the availability of complete fungal genome sequences and efficient gene-disruption techniques for fungi, approaches are now feasible to delineate biosynthetic pathways for ETPs and to gain insights into the evolution of such gene clusters.
Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
- T. Rouxel, Jonathan Grandaubert, B. Howlett
- BiologyNature Communications
- 15 February 2011
The genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans is reported and its repertoire of protein effectors is characterized, revealing an unusual bipartite structure that underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.
Secondary metabolism: regulation and role in fungal biology.
- E. M. Fox, B. Howlett
- BiologyCurrent Opinion in Microbiology
- 1 December 2008
Current knowledge of the interaction between Brassica napus and Leptosphaeria maculans
- B. Howlett
- 1 September 2004
The application of genomic technologies to both partners in the interaction is uncovering details of pathogenicity mechanism used by L. maculans, and defence responses by its host, B. napus.
The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans
- D. Gardiner, A. Cozijnsen, L. Wilson, M. S. C. Pedras, B. Howlett
- BiologyMolecular Microbiology
- 1 September 2004
This is the first report of the genes responsible for the biosynthesis of an ETP, and it is shown via gene disruption that one of these genes (encoding a two‐module non‐ribosomal peptide synthetase) is essential for sirodesmin PL biosynthesis.
Major gene resistance in Brassica napus (oilseed rape) is overcome by changes in virulence of populations of Leptosphaeria maculans in France and Australia
- S. Sprague, M. Balesdent, B. Howlett
- BiologyEuropean journal of plant pathology
Resistance of Brassica napus (oilseed rape, canola) conferred by three different major resistance genes has been overcome by changes in virulence of Leptosphaeria maculans populations in France and…
Microsatellite markers reveal genetic differentiation among populations of Sclerotinia sclerotiorum from Australian canola fields
- A. Sexton, B. Howlett
- BiologyCurrent Genetics
- 10 November 2004
Genotypic disequilibrium analyses on each of the four populations suggested that both clonal and sexual reproduction contributed to population structure, and moderate to high level of differentiation was demonstrated.
Leptosphaeria maculans, the causal agent of blackleg disease of Brassicas.
- B. Howlett, A. Idnurm, M. Pedras
- BiologyFungal Genetics and Biology
- 1 June 2001
Chemical analysis of fungal secondary metabolites has aided understanding of taxonomic relationships and of the host-fungal interaction by the unraveling of pathways for detoxification of antimicrobial phytoalexins.