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Glioblastoma
Known as:
Grade IV Astrocytic Neoplasm
, WHO Grade IV Glioma
, Glioblastoma, NOS
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The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the…
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National Institutes of Health
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Related topics
Related topics
48 relations
Anaplasia
Anaplastic astrocytoma
Blood supply aspects
Carmustine
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Broader (4)
Astrocytoma
Glioma
Malignant neoplasm of brain
carcinoma brain
Narrower (1)
Glioblastoma Multiforme
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
D. Louis
,
A. Perry
,
+7 authors
D. Ellison
Acta Neuropathologica
2016
Corpus ID: 3345100
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical…
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Highly Cited
2014
Highly Cited
2014
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel
,
I. Tirosh
,
+12 authors
B. Bernstein
Science
2014
Corpus ID: 6627369
Cancer at single-cell resolution Single-cell sequencing can illuminate the genetic properties of brain cancers and reveal…
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Highly Cited
2014
Highly Cited
2014
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
O. Chinot
,
W. Wick
,
+11 authors
T. Cloughesy
New England Journal of Medicine
2014
Corpus ID: 205096002
BACKGROUND Standard therapy for newly diagnosed glioblastoma is radiotherapy plus temozolomide. In this phase 3 study, we…
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Review
2013
Review
2013
Glioblastoma and other malignant gliomas: a clinical review.
A. Omuro
,
L. Deangelis
Journal of the American Medical Association (JAMA…
2013
Corpus ID: 11856145
IMPORTANCE Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5…
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Highly Cited
2008
Highly Cited
2008
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
R. McLendon
,
A. Friedman
,
+228 authors
E. Thomson
Nature
2008
Corpus ID: 1836154
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that…
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Highly Cited
2008
Highly Cited
2008
Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers
J. Skog
,
T. Wurdinger
,
+7 authors
X. Breakefield
Nature Cell Biology
2008
Corpus ID: 1267605
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles…
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Review
2008
Review
2008
Malignant gliomas in adults.
P. Wen
,
S. Kesari
New England Journal of Medicine
2008
Corpus ID: 41225938
Approximately 5% of patients with malignant gliomas have a family history of gliomas. Some of these familial cases are associated…
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Review
2007
Review
2007
Genetic pathways to primary and secondary glioblastoma.
H. Ohgaki
,
P. Kleihues
American Journal of Pathology
2007
Corpus ID: 6818336
Glioblastoma is the most frequent and most malignant human brain tumor. The prognosis remains very poor, with most patients dying…
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Highly Cited
2005
Highly Cited
2005
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
R. Stupp
,
Warren P. Mason
,
+16 authors
R. Mirimanoff
New England Journal of Medicine
2005
Corpus ID: 41340212
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care…
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Highly Cited
2005
Highly Cited
2005
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
J. Chan
,
Anna M. Krichevsky
,
K. Kosik
Cancer Research
2005
Corpus ID: 7928715
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding…
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