• Publications
  • Influence
Melanin pigmentation in mammalian skin and its hormonal regulation.
Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait. Expand
Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.
The findings suggest that the large size of a (GT)n repeat in the HO-1 gene promoter may reduceHO-1 inducibility by reactive oxygen species in cigarette smoke, thereby resulting in the development of CPE. Expand
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
regulation of ho‐1 involves a direct sensing of heme levels by Bach1 (by analogy to lac repressor sensitivity to lactose), generating a simple feedback loop whereby the substrate effects repressor–activator antagonism. Expand
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
It is shown that heme binds specifically to Bach1 and regulates its DNA‐binding activity, suggesting that increased levels of heme inactivate the repressor Bach1, resulting in induction of a host of genes with MAREs. Expand
Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a*
Exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates the expression of endogenous melanocyte-specific Mitf (Mitf-M) mRNA in cultured melanocytes, and is identified as a direct target of Wnt signaling. Expand
Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells*
Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells, indicating the inter-species difference in the hypoxic regulation ofHO-1 expression. Expand
Cloning and expression of cDNA for rat heme oxygenase.
Two cDNA clones for rat heme oxygenase have been isolated from a rat spleen cDNA library in lambda gt11 by immunological screening using a specific polyclonal antibody and RNA blot analysis showed that both CoCl2 and hemin increased the amount of hybridizable mRNA, suggesting that these substances may act at the transcriptional level to increase the amount. Expand
The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism.
  • S. Shibahara
  • Biology, Medicine
  • The Tohoku journal of experimental medicine
  • 1 August 2003
The potential regulatory role of Bach1 and HO-2 in heme catabolism is discussed, long (GT)n alleles are associated with susceptibility to smoking-induced emphysema or coronary artery disease, but may provide with resistance to cerebral malaria, and a novel therapeutic strategy with inhibitors of HO-1 for the treatment of cerebral malaria is suggested. Expand
Functional Analysis of Microphthalmia-associated Transcription Factor in Pigment Cell-specific Transcription of the Human Tyrosinase Family Genes*
It is suggested that microphthalmia-associated transcription factor (MITF) is sufficient to direct pigment cell-specific transcription of the tyrosinase and TRP-1 genes but not theTRP-2 gene. Expand
Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium.
A novel Mitf isoform, Mitf-a, and its human homologue MITF-A are identified by cDNA cloning and suggested to play an important role in melanogenesis in RPE. Expand