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Genes, Suppressor

Known as: Gene, Second-Site Suppressor, Gene, Suppressor, gene suppressor 
Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild… 
National Institutes of Health

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Genes, Amber SuppressorGenes, Frameshift SuppressorGenes, Ochre SuppressorGenes, Opal Suppressor
Suppression, Geneticaspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2011
Highly Cited
2011
(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.
The anti-skin carcinogenic effects of green tea catechins have been studied extensively in vitro and in vivo models but the… 
Highly Cited
2010
Highly Cited
2010
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancer
MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of approximately 60% of all human genes. They play… 
Highly Cited
2003
Highly Cited
2003
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common… 
Highly Cited
2000
Highly Cited
2000
Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.
We previously showed that introduction of a normal, neomycin-tagged human chromosome 11 reduces the metastatic capacity of MDA-MB… 
Review
1994
Review
1994
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.
The p53 tumour-suppressor gene is mutated in 60% of human tumours, and the product of the gene acts as a suppressor of cell… 
Review
1993
Review
1993
The tumor suppressor genes.
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES… 
Highly Cited
1992
Highly Cited
1992
Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.
BACKGROUND Mutations of the tumor suppressor gene p53 have been identified in breast cancer cell lines, and some breast… 
Highly Cited
1991
Highly Cited
1991
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
The tumour suppressor gene p53 has been found to be mutated or inactivated at high frequency in several common human tumours. We… 
Highly Cited
1990
Highly Cited
1990
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines
Human T-cell leukemia and T-cell acute lymphoblastic leukemia cell lines were studied for alterations in the p53 tumor suppressor… 
Highly Cited
1989
Highly Cited
1989
Tumor suppressor genes: the puzzle and the promise.
Tumor suppressor genes are wild-type alleles of genes that play regulatory roles in cell proliferation, differentiation, and… 
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