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Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
Blockade of pathways mediating macrophage recruitment, in combination with chemotherapy, significantly decreases primary tumor progression, reduces metastasis, and improves survival by CD8+ T-cell-dependent mechanisms, thus indicating that the immune microenvironment of tumors can be reprogrammed to instead foster antitumor immunity and improve response to cytotoxic therapy. Expand
A microRNA DNA methylation signature for human cancer metastasis
- A. Lujambio, G. Calin, +11 authors M. Esteller
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 9 September 2008
Findings indicate that DNA methylation-associated silencing of tumor suppressor miRNAs contributes to the development of human cancer metastasis. Expand
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.
These findings show how targeting TAMs can effectively overcome therapeutic resistance mediated by TICs and improve chemotherapeutic efficacy, inhibits metastasis, and increases antitumor T-cell responses. Expand
Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy
The aim of this review is to provide an insight into PDT photosensitizers clinically approved for application in oncology, as well as those which show significant potential in ongoing preclinical studies. Expand
SATB2 in Combination With Cytokeratin 20 Identifies Over 95% of all Colorectal Carcinomas
- K. Magnusson, M. de Wit, +25 authors F. Pontén
- The American journal of surgical pathology
- 1 July 2011
The specific expression of SATB2 in a large majority of CRCs suggests that SATB 2 can be used as an important complementary tool for the differential diagnosis of carcinoma of unknown primary origin. Expand
Fibulins: physiological and disease perspectives
Findings from studies of animal models of fibulin deficiency, human fibulin gene mutations, human tumours and injury models that have advanced understanding of the normal and pathological roles of members of this formerly obscure family are summarized. Expand
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
This study confirms that multiple mechanisms contribute to Docetaxel resistance and the central transcription factor NF-κB plays an immensely important role in determining docetaxe-resistance which may represent an appropriate therapeutic target. Expand
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
- C. Lindsay, Samuel O. Lawn, +31 authors O. Sansom
- Biology, Medicine
- Nature communications
- 22 November 2011
It is concluded that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans. Expand
BreastMark: An Integrated Approach to Mining Publicly Available Transcriptomic Datasets Relating to Breast Cancer Outcome
BreastMark is a powerful tool for examining putative gene/miRNA prognostic markers in breast cancer, and can act as a powerful reductionist approach to these more complex gene signatures, eliminating superfluous genes, potentially reducing the cost and complexity of these multi-index assays. Expand
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Expand