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Ganciclovir

Known as: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol, 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, Nordeoxyguanosine 
A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears… 
National Institutes of Health

Related topics

Related topics

34 relations

Narrower (11)

1-O-hexadecylpropanediol-3-phospho-penciclovir6-deoxyganciclovir dipivalate esterBIOLF-62Cymevan
AIDS-Related Opportunistic InfectionsCytomegalovirus InfectionsCytomegalovirus RetinitisDecreased Protein Synthesis [PE]

Broader (2)

Antiviral AgentsNucleoside Analogs

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.
Gene-directed enzyme prodrug therapy (GDEPT) is a two step therapeutic approach for cancer gene therapy. In the first step, the… 
Highly Cited
2002
Highly Cited
2002
Randomized multicenter trial of foscarnet versus ganciclovir for preemptive therapy of cytomegalovirus infection after allogeneic stem cell transplantation.
The present study compared foscarnet with ganciclovir for preemptive therapy of cytomegalovirus (CMV) infection after allogeneic… 
Highly Cited
2001
Highly Cited
2001
Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
The activation of group I metabotropic glutamate receptors (mGluRs) produces a variety of actions that lead to alterations in… 
Highly Cited
2001
Highly Cited
2001
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.
Recent work has demonstrated that specific patterns of synaptic stimulation can induce long-term depression (LTD) in area CA1… 
Highly Cited
1992
Highly Cited
1992
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
HUMAN cytomegalovirus (HCMV) is a major pathogen in immunosuppressed individuals, including patients with acquired immune… 
Highly Cited
1992
Highly Cited
1992
Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir
HUMAN cytomegalovirus (HCMV, a betaherpes virus) is the cause of serious disease in immunologically compromised individuals… 
Highly Cited
1991
Highly Cited
1991
Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation.
BACKGROUND Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality after allogeneic bone marrow… 
Highly Cited
1991
Highly Cited
1991
Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection.
Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the… 
Highly Cited
1989
Highly Cited
1989
Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients.
CYTOMEGALOVIRUS (CMV) infections are a major cause of morbidity and mortality among immunocompromised patients, especially… 
Highly Cited
1988
Highly Cited
1988
Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin.
STUDY OBJECTIVE To assess the efficacy of the combination of the antiviral agent ganciclovir (9-1,3 dihydroxy-2… 
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