A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells

@article{Sullivan1992APK,
  title={A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells},
  author={V. Sullivan and C. Talarico and S. Stanat and M. Davis and D. Coen and K. Biron},
  journal={Nature},
  year={1992},
  volume={358},
  pages={162-164}
}
HUMAN cytomegalovirus (HCMV) is a major pathogen in immunosuppressed individuals, including patients with acquired immune deficiency syndrome. The nucleoside analogue ganciclovir (9-(l,3-dihydroxy-2-propoxymethyl)-guanine) is one of the few drugs available to treat HCMV infections, but resistant virus is a growing problem in the clinic1 and there is a critical need for new drugs. The study of ganciclovir-resistant mutants has indicated that the selective action of ganciclovir depends largely on… Expand
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