Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir

@article{Littler1992HumanCU,
  title={Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir},
  author={Edward Littler and Amanda D. Stuart and Mark S. Chee},
  journal={Nature},
  year={1992},
  volume={358},
  pages={160-162}
}
HUMAN cytomegalovirus (HCMV, a betaherpes virus) is the cause of serious disease in immunologically compromised individuals, including those with acquired immunodeficiency syndonie1. One of the compounds used in the chemotherapy of HCMV infections is the nucleoside analogue 9-(l,3-dihydroxy-2-propoxymethyl)-guanine (ganciclovir). The mechanism of action of this drug is dependent on the formation of the nucleoside triphosphate, which is a strong inhibitor of the viral DNA polymerase2–4… CONTINUE READING

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