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A second generation human haplotype map of over 3.1 million SNPs
The Phase II HapMap is described, which characterizes over 3.1 million human single nucleotide polymorphisms genotyped in 270 individuals from four geographically diverse populations and includes 25–35% of common SNP variation in the populations surveyed, and increased differentiation at non-synonymous, compared to synonymous, SNPs is demonstrated.
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.
This chapter is being written in March 1989 when the sequence is complete except for some remaining polishing of certain areas which is still going on (manuscript in preparation).
Expression monitoring by hybridization to high-density oligonucleotide arrays
This work has developed an approach that is based on hybridization to small, high-density arrays containing tens of thousands of synthetic oligonucleotides that provides a way to use directly the growing body of sequence information for highly parallel experimental investigations.
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome.
A large-scale survey for SNPs was examined by a combination of gel-based sequencing and high-density variation-detection DNA chips, and a genetic map was constructed showing the location of 2227 candidate SNPs.
Highly parallel SNP genotyping.
An integrated SNP genotyping system that combines a highly multiplexed assay with an accurate readout technology based on random arrays of DNA-coated beads is developed that helps enable genome-wide association studies and other large-scale genetic analysis projects.
High-throughput DNA methylation profiling using universal bead arrays.
The results demonstrate the effectiveness of the method for reliably profiling many CpG sites in parallel for the discovery of informative methylation markers and should prove useful for DNA methylation analyses in large populations.
The DNA sequence of the human cytomegalovirus genome.
The 229 kilobase pair DNA genome of human cytomegalovirus (HCMV) strain AD169 is the largest contiguous sequence determined to date, and as such provides a realistic benchmark for assessing the practical rate of DNA sequencing as opposed to theoretical calculations which are usually much greater.
Accessing Genetic Information with High-Density DNA Arrays
The simultaneous analysis of the entire human mitochondrial genome is described here and can be used to address a variety of questions in molecular genetics including gene expression, genetic linkage, and genetic variability.
Human cytomegalovirus encodes three G protein-coupled receptor homologues
A family of three HCMV genes which encode polypeptides containing seven putative membrane-spanning domains, and a series of well-defined motifs characteristic of the rhodopsin-like G protein-coupled receptors (GCRs) are identified, which could permit the development of a novel class of antiviral drugs analogous to β-adrenergic receptor antagonists.
Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.
A genes in human cytomegalovirus and a homologous gene in human herpesvirus 6 which could specify a product related to protein kinases are sequenced which may represent a significant departure from known protein kinase in terms of structure and/or function.