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Galectin 1

Known as: Galactoside-Binding Lectin 1, Galectin 1 [Chemical/Ingredient], 14 kDa Lectin 
Galectin-1 (135 aa, ~15 kDa) is encoded by the human LGALS1 gene. This protein may play a role in modulating cell-cell and cell-matrix interactions… 
National Institutes of Health

Related topics

Related topics

17 relations
ApoptosisExtracellular MatrixIn BloodLGALS1 gene

Broader (1)

Galactose Binding Lectin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in… 
Highly Cited
2000
Highly Cited
2000
Expression of galectin‐1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin‐1 inhibits the growth of 9 glioma cells
Although its precise function has not yet been established, galectin‐1 seems to play a role in tumor progression. In this study… 
Highly Cited
2000
Highly Cited
2000
Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells.
Galectin-1 (gal-1) a member of the mammalian beta-galactoside-binding proteins recognizes preferentially Galbeta1-4GlcNAc… 
Highly Cited
1999
Highly Cited
1999
Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation.
Galectin-1 is an endogenous lectin expressed by thymic and lymph node stromal cells at sites of Ag presentation and T cell death… 
Highly Cited
1999
Highly Cited
1999
The levels of expression of galectin‐1, galectin‐3, and the Thomsen–Friedenreich antigen and their binding sites decrease as clinical aggressiveness increases in head and neck cancers
The aim of this study was to investigate whether an increase in malignancy level is accompanied by significant modifications of… 
Highly Cited
1995
Highly Cited
1995
Rapid mass spectrometric peptide sequencing and mass matching for characterization of human melanoma proteins isolated by two-dimensional PAGE.
We report a general mass spectrometric approach for the rapid identification and characterization of proteins isolated by… 
Review
1995
Review
1995
Tissue fibronectin is an endogenous ligand for galectin-1.
A 14K beta-galactoside-binding lectin (galectin-1) is present in many animal tissues. In a search for endogenous ligands, we… 
Highly Cited
1993
Highly Cited
1993
Galaptin-mediated adhesion of human ovarian carcinoma A121 cells and detection of cellular galaptin-binding glycoproteins.
Previously, we have shown that galaptin, an endogenous beta-galactoside-binding lectin, is present in extracellular matrix where… 
Highly Cited
1984
Highly Cited
1984
Peanut lectin binding sites in transitional cell carcinoma of the urinary bladder
Peanut lectin (PNA) binds to D Gal B (1–3) D Gal NAc which is the purported antigenic determinant of the so‐called T blood group… 
Highly Cited
1981
Highly Cited
1981
Preparative nonlytic separation of Lyt2+ and Lyt2− T lymphocytes, functional analyses of the separated cells and demonstration of synergy in graft‐vs.‐host reaction of Lyt2+ and Lyt2− cells
A convenient, preparative scale, nonlytic separation of mouse T lymphocytes into Lyt2.2+ and Lyt2.2− populations is reported… 
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