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C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
TLDR
Results indicate that Mincle is the first specific receptor for Malassezia species to be reported and plays a crucial role in immune responses to this fungus.
Galectin-3 Interaction with Thomsen-Friedenreich Disaccharide on Cancer-associated MUC1 Causes Increased Cancer Cell Endothelial Adhesion*
TLDR
It is reported that MUC1, a large transmembrane mucin protein that is overexpressed and aberrantly glycosylated in epithelial cancer, is a natural ligand for galectin-3, which promotes cancer cell adhesion to endothelium by revealing epithelial adhesion molecules that are otherwise concealed by M UC1.
The family of metazoan metal-independent beta-galactoside-binding lectins: structure, function and molecular evolution.
TLDR
It appears that beta-galactoside-binding lectins and some non-lectin proteins form a superfamily whose members are widely distributed from vertebrates to invertebrates and a consideration of molecular evolution suggests that lectins belonging to this family probably existed in the Precambrian era.
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins
TLDR
The approach, termed isotope-coded glycosylation-site-specific tagging (IGOT), is based on the lectin column–mediated affinity capture of a set of glycopeptides generated by tryptic digestion of protein mixtures, followed by peptide-N-glycosidase–mediated incorporation of a stable isotope tag, 18O, specifically into the N-glyCosylation site.
Visualization of Galectin-3 Oligomerization on the Surface of Neutrophils and Endothelial Cells Using Fluorescence Resonance Energy Transfer*
TLDR
Data suggest that galectin-3 lattices are robust and could, thus, be involved, as previously proposed, in the restriction of receptor clustering, and lattice formation.
Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling
TLDR
A new microarray procedure based on an evanescent-field fluorescence-detection principle that allows sensitive, real-time observation of multiple lectin-carbohydrate interactions under equilibrium conditions is described, which should contribute to creation of a new paradigm for glycomics.
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