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WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development
The results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation.
Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors
A complete BR signalling pathway is described by elucidating key missing steps and new insights are provided into the mechanism of GSK3 regulation.
BSKs Mediate Signal Transduction from the Receptor Kinase BRI1 in Arabidopsis
Genetic and transgenic studies demonstrate that BSKs are the substrates of BRI1 kinase that activate downstream BR signal transduction.
Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching.
This work explores the advantage of using accurate mass measurement (and thus constraint on the possible elemental composition of components in a protein digest) in strategies for searching protein, gene, and EST databases that employ mass values alone, fragment-ion tagging derived from MS/MS spectra, and de novo interpretation of MS/ MS spectra.
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
NETO2 is a kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain and it is found that kainates receptors regulate the surface expression of NETO2 and that NETO 2 protein levels and surface expression are decreased in mice lacking the kainATE receptor GluR6.
The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2.
A complete phosphorylation/dephosphorylation cascade linking a steroid-activated receptor kinase to a GSK3-like kinase in plants is demonstrated and confirmed that CDG1 and its homolog CDL1 positively regulate BR signaling and plant growth.
Global landscape of HIV–human protein complexes
The use of affinity tagging and purification mass spectrometry is reported to determine systematically the physical interactions of all 18 HIV-1 proteins and polyproteins with host proteins in two different human cell lines (HEK293 and Jurkat).
Structural identification of autoinducer of Photobacterium fischeri luciferase.
Synthesis of bacterial luciferase in some strains of luminous bacteria requires a threshold concentration of an autoinducer synthesized by the bacteria and excreted into the medium. Autoinducer
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
It is shown by direct protein delivery into mammalian cells that an HP1 α mutant incapable of phase separation in vitro forms smaller and fewer nuclear puncta than phosphorylated HP1α, suggesting that heterochromatin-mediated gene silencing may occur in part through sequestration of compacted chromatin in phase-separated HP1 droplets, which are dissolved or formed by specific ligands on the basis of nuclear context.
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis.
It is shown that H3 K56ac is also present during premeiotic S phase and is conserved in fission yeast, and Mutational analysis of Asf1 demonstrates that DNA damage sensitivity correlates with decreased levels of H3K56ac and a region implicated in histone binding.