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Gabexate

Known as: Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester, Ethyl p-hydroxybenzoate 6-guanidinohexanoate, Gabexate [Chemical/Ingredient] 
A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (2)

AnticoagulantsSerine Proteinase Inhibitors

Narrower (3)

FoyGabexate Methanesulfonatecamostat
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Somatostatin and gabexate for post‐endoscopic retrograde cholangiopancreatography pancreatitis prevention: Meta‐analysis of randomized placebo‐controlled trials
Background and Aim:  Prior studies have suggested the efficacy of somatostatin and gabexate in post‐endoscopic retrograde… 
2006
2006
Evaluation of a protease inhibitor in the prevention of ischemia and reperfusion injury in hepatectomy under intermittent Pringle maneuver.
2002
2002
Pancreatic Protease Inhibition during Shock Attenuates Cell Activation and Peripheral Inflammation
Intestinal ischemia contributes to shock-induced multiple organ failure. Our recent evidence suggests that pancreatic proteases… 
2002
2002
Effects of Gabexate Mesilate, a Protease Inhibitor, on Human Sphincter of Oddi Motility
Gabexate mesilate is an antiprotease drug, which reduced the severity of pancreatitis and frequency of post-ERCP pancreatitis. In… 
1998
1998
Permeability Characteristics of Tetragastrins Across Intestinal Membranes Using the Caco-2 Monolayer System: Comparison Between Acylation and Application of Protease Inhibitors
AbstractPurpose. Three types of acyl tetragastrin (TG), acetyl-TG (C2-TG), butyryl-TG (C4-TG) and caproyl-TG (C6-TG) were… 
1997
1997
Gabexate mesilate improves pancreatic microcirculation and reduces lung edema in a rat model of acute pancreatitis.
We evaluated the effects of a protease inhibitor on the progression of acute pancreatitis in rats. The model was selected and… 
1995
1995
Effectiveness of gabexate mesilate in acute pancreatitis
Since the effectiveness of gabexate mesilate in patients with acute pancreatitis is controversial, a metaanalysis of the… 
1991
1991
Thrombin decreases glycosaminoglycans content of endothelial cells in culture.
1986
1986
Protective effect of CR 1409 (cholecystokinin antagonist) on experimental pancreatitis in rats and mice
1984
1984
Anticoagulation with a synthetic thrombin inhibitor after cardiovascular surgery and for treatment of disseminated intravascular coagulation
A synthetic thrombin inhibitor, MD-805, was used to anticoagulate 15 patients after cardiovascular surgery (CVS). A mean infusion… 
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