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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
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Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet
TLDR
In mice, endocannabinoids modulate insulin release from pancreatic β‐cells and adipokine expression in adipocytes through cannabinoid receptors through cannabinoids receptors, and these alterations are elevated during hyperglycemia and obesity.
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Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
TLDR
It is concluded that inflammation of the gut increases the potency of cannabinoid agonists possibly by ‘up‐regulating’ CB1 receptor expression; in addition, endocannabinoids, whose turnover is increased in inflamed gut, might tonically inhibit intestinal motility.
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Milk thistle in liver diseases: past, present, future
TLDR
Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin‐induced liver diseases, and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors.
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Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
TLDR
It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms in colorectal carcinoma cell lines.
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Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
TLDR
Cannabidiol, a likely safe compound, prevents experimental colitis in mice and reduces colon injury and endocannabinoid changes associated with 2,4,6-dinitrobenzene sulfonic acid administration.
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Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
View on Elsevier
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
TLDR
It is concluded that pharmacological enhancement of endocannabinoid levels (through inhibition of endOCannabinoid hydrolysis) reduces the development of precancerous lesions in the mouse colon.
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Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases
TLDR
Overall, literature data suggest that, despite encouraging preclinical data, further well‐designed randomized clinical trials are needed to fully substantiate the real value of MT preparations in liver diseases.
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Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti‐inflammatory agent
TLDR
The effect of PEA is investigated in a murine model of colitis by studying its role in the regulation of intestinal inflammation through modulation of G protein‐coupled receptor 55.
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