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GW1843

National Institutes of Health

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1843U89

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients
Objectives: Although methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis (RA), patients experience… 
2005
2005
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells
Purpose: Trifluorothymidine (TFT) is a fluoropyrimidine that is part of the novel combination metabolite TAS-102, in which TFT is… 
2005
2005
Antifolates Folates and Can Mediate Cellular Resistance against The Human Multidrug Resistance Protein MRP 5 Transports
Members of the multidrug resistance protein family, notably MRP1-4/ABCC1-4, and the breast cancer resistance protein BCRP/ABCG2… 
2000
2000
Advances in Brief Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP 1 and MRP 21
Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level… 
1998
1998
Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in…
Thymidylate synthase (TS) inhibition causes cell death, and this enzyme is the target for the important chemotherapy regime 5… 
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