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GSTA4 protein, human

Known as: Glutathione S-Aralkyltransferase A4, glutathione S-transferase A4, human, hGSTA4 protein, human 
Glutathione S-transferase A4 (222 aa, ~26 kDa) is encoded by the human GSTA4 gene. This protein is involved in the conjugation of reduced glutathione… 
National Institutes of Health

Related topics

Related topics

10 relations
Biogenic Amine Metabolic ProcessCytoplasmic matrixEnzyme GeneGSTA4 gene

Broader (1)

leukotriene-C4 synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury.
Review
2005
Review
2005
Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease.
Highly Cited
2005
Highly Cited
2005
The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cells
Purpose: The gut fermentation product of dietary fiber, butyrate, inhibits growth of HT29, an established tumor cell line. It… 
Highly Cited
2005
Highly Cited
2005
Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate.
The cellular production of 4-hydroxy-2-nonenal (HNE), a product of endogenous lipid peroxidation, constitutes a genotoxic risk… 
Highly Cited
2004
Highly Cited
2004
Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis.
Highly Cited
2004
Highly Cited
2004
Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells.
4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a… 
Review
2003
Review
2003
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling.
Review
2003
Review
2003
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.
Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear… 
2003
2003
Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts.
Human glutathione (GSH) transferase (hGSTP1-1) processes with similar kinetic efficiencies the antitumor agents 2… 
2001
2001
Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria.
The reactive cellular products generated during the peroxidation of membrane lipids have been implicated as causative agents in a… 
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