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GSTA4 gene

Known as: glutathione S-transferase alpha 4, Glutathione S-Transferase Alpha 4 Gene, GLUTATHIONE S-TRANSFERASE A4 
This gene is involved in the metabolism of small molecules and xenobiotics.
National Institutes of Health

Related topics

Related topics

4 relations
Biogenic Amine Metabolic ProcessGSTA4 protein, humanGlutathione S-Transferasexenobiotic metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.
4-Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO), has been shown to induce apoptosis… Expand
Review
2011
Review
2011
Interactions of glutathione transferases with 4-hydroxynonenal
Electrophilic products of lipid peroxidation are important contributors to the progression of several pathological states. The… Expand
Highly Cited
2010
Highly Cited
2010
Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the… Expand
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Highly Cited
2008
Highly Cited
2008
4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase
Introduction4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts… Expand
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Highly Cited
2007
Highly Cited
2007
Functional Promiscuity Correlates with Conformational Heterogeneity in A-class Glutathione S-Transferases*
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ greatly in their relative catalytic… Expand
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Highly Cited
2006
Highly Cited
2006
Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin
We investigated the cytoprotective mechanisms of flunarizine in cisplatin-induced death of auditory cells. Concomitant with an… Expand
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Review
2005
Review
2005
Glutathione transferases.
This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal… Expand
Review
2003
Review
2003
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.
Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear… Expand
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Highly Cited
2003
Highly Cited
2003
Phosphorylation Enhances Mitochondrial Targeting of GSTA4-4 through Increased Affinity for Binding to Cytoplasmic Hsp70*
Recently we showed that three different isoforms of cytosolic glutathione S-transferases (GST), including GSTA4-4, are also… Expand
Highly Cited
1998
Highly Cited
1998
Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
  • P. Board
  • The Biochemical journal
  • 1998
    • Corpus ID: 13083850
The Expressed Sequence Tag database has been searched for examples of previously undescribed human Alpha class glutathione… Expand
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