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GSTA4 gene
Known as:
glutathione S-transferase alpha 4
, Glutathione S-Transferase Alpha 4 Gene
, GLUTATHIONE S-TRANSFERASE A4
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This gene is involved in the metabolism of small molecules and xenobiotics.
National Institutes of Health
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Related topics
Related topics
4 relations
Biogenic Amine Metabolic Process
GSTA4 protein, human
Glutathione S-Transferase
xenobiotic metabolism
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.
S. Singhal
,
Sharda P. Singh
,
P. Singhal
,
D. Horne
,
J. Singhal
,
S. Awasthi
Toxicology and applied pharmacology
2015
Corpus ID: 7418067
Highly Cited
2010
Highly Cited
2010
Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
J. Curtis
,
Paul A. Grimsrud
,
+10 authors
D. Bernlohr
Diabetes
2010
Corpus ID: 14976501
OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the…
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Highly Cited
2008
Highly Cited
2008
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.
Abha Sharma
,
Rajendra K. Sharma
,
+6 authors
Y. Awasthi
Archives of biochemistry and biophysics
2008
Corpus ID: 399890
Highly Cited
2007
Highly Cited
2007
Functional Promiscuity Correlates with Conformational Heterogeneity in A-class Glutathione S-Transferases*
Liming Hou
,
Matthew T. Honaker
,
+5 authors
W. Atkins
Journal of Biological Chemistry
2007
Corpus ID: 25295125
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ greatly in their relative catalytic…
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Highly Cited
2006
Highly Cited
2006
Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin
H. So
,
H. Kim
,
+11 authors
R. Park
Cell Death and Differentiation
2006
Corpus ID: 2042352
We investigated the cytoprotective mechanisms of flunarizine in cisplatin-induced death of auditory cells. Concomitant with an…
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Highly Cited
2006
Highly Cited
2006
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: Mechanism of neurodegeneration
Suman Patel
,
V. Singh
,
Abhai Kumar
,
Y. Gupta
,
M. Singh
Brain Research
2006
Corpus ID: 10401337
Review
2005
Review
2005
Glutathione transferases.
J. Hayes
,
J. Flanagan
,
I. Jowsey
Annual review of pharmacology and toxicology
2005
Corpus ID: 44655892
This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal…
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Review
2003
Review
2003
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.
Yusong Yang
,
Rajendra K. Sharma
,
Abha Sharma
,
S. Awasthi
,
Y. Awasthi
Acta biochimica Polonica
2003
Corpus ID: 13099913
Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear…
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Highly Cited
2003
Highly Cited
2003
Phosphorylation Enhances Mitochondrial Targeting of GSTA4-4 through Increased Affinity for Binding to Cytoplasmic Hsp70*
M. Robin
,
S. K. Prabu
,
H. Raza
,
H. Anandatheerthavarada
,
N. Avadhani
Journal of Biological Chemistry
2003
Corpus ID: 10502658
Recently we showed that three different isoforms of cytosolic glutathione S-transferases (GST), including GSTA4-4, are also…
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2002
2002
Pro-inflammatory Cytokines Tumor Necrosis Factor α and Interleukin-6 and Survival Factor Epidermal Growth Factor Positively Regulate the Murine GSTA4 Enzyme in Hepatocytes*
F. Desmots
,
M. Rissel
,
+5 authors
P. Loyer
The Journal of Biological Chemistry
2002
Corpus ID: 25095978
We hypothesized that glutathione transferases could be induced and may participate to cellular defenses against the oxidative…
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