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GSTA4 gene

Known as: glutathione S-transferase alpha 4, Glutathione S-Transferase Alpha 4 Gene, GLUTATHIONE S-TRANSFERASE A4 
This gene is involved in the metabolism of small molecules and xenobiotics.
National Institutes of Health

Related topics

Related topics

4 relations
Biogenic Amine Metabolic ProcessGSTA4 protein, humanGlutathione S-Transferasexenobiotic metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction
OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the… Expand
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2008
2008
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells.
4-hydroxy-trans-2-nonenal (HNE) is one of the most abundant and toxic lipid aldehydes formed during lipid peroxidation by… Expand
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2008
2008
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.
4-Hydroxynonenal (4-HNE) has been suggested to be involved in stress-induced signaling for apoptosis. In present studies, we have… Expand
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2006
2006
The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice.
Glutathione S-transferases (GSTs) play a key role in cellular detoxification of environmental toxicants through their conjugation… Expand
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Highly Cited
2005
Highly Cited
2005
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
OBJECTIVES Sporadic colorectal cancer (CRC) is considered a multifactorial disease where multiple exposures interact with the… Expand
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Highly Cited
2003
Highly Cited
2003
Phosphorylation Enhances Mitochondrial Targeting of GSTA4-4 through Increased Affinity for Binding to Cytoplasmic Hsp70*
Recently we showed that three different isoforms of cytosolic glutathione S-transferases (GST), including GSTA4-4, are also… Expand
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Review
2003
Review
2003
Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.
Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear… Expand
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2002
2002
Pro-inflammatory Cytokines Tumor Necrosis Factor α and Interleukin-6 and Survival Factor Epidermal Growth Factor Positively Regulate the Murine GSTA4 Enzyme in Hepatocytes*
We hypothesized that glutathione transferases could be induced and may participate to cellular defenses against the oxidative… Expand
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2000
2000
Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver.
During oxidative stress, reactive aldehydes, including trans-4-hydroxy-2-nonenal (4-HNE), are generated by peroxidation of… Expand
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1998
1998
Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
The Expressed Sequence Tag database has been searched for examples of previously undescribed human Alpha class glutathione… Expand
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