FAQ

GSTA4 gene

Known as: glutathione S-transferase alpha 4, Glutathione S-Transferase Alpha 4 Gene, GLUTATHIONE S-TRANSFERASE A4 
This gene is involved in the metabolism of small molecules and xenobiotics.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2018
051019932018

Related topics

Related topics

4 relations
Biogenic Amine Metabolic ProcessGSTA4 protein, humanGlutathione S-Transferasexenobiotic metabolism

Related mentions per year

Related mentions per year

1963-2018
1960198020002020
GSTA4 gene
Glutathione S-Transferase
xenobiotic metabolism
Biogenic Amine Metabolic Process
GSTA4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Oxidative stress is reported as one of the most widely accepted mechanisms of maneb (MB)- and paraquat (PQ)-induced nigrostriatal… (More)
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2011
2011
Increased adipose protein carbonylation in human obesity.
Insulin resistance is associated with obesity but mechanisms controlling this relationship in humans are not fully understood… (More)
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2010
2010
Effects of cypermethrin on monoamine transporters, xenobiotic metabolizing enzymes and lipid peroxidation in the rat nigrostriatal system.
Long-term exposure to cypermethrin induces the nigrostriatal dopaminergic neurodegeneration in adult rats and its pre-exposure in… (More)
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2010
2010
Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
BACKGROUND The incidence of nonmelanoma skin cancer (NMSC) is equivalent to that of all other cancers combined. Previously, we… (More)
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2008
2008
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells.
4-hydroxy-trans-2-nonenal (HNE) is one of the most abundant and toxic lipid aldehydes formed during lipid peroxidation by… (More)
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2007
2007
Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases.
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ greatly in their relative catalytic… (More)
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2007
2007
4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes.
Oxidative stress has been implicated in the pathogenesis of several neurodegenerative disorders including primary open-angle… (More)
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Highly Cited
2005
Highly Cited
2005
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
OBJECTIVES Sporadic colorectal cancer (CRC) is considered a multifactorial disease where multiple exposures interact with the… (More)
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2003
2003
Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.
Recently we showed that three different isoforms of cytosolic glutathione S-transferases (GST), including GSTA4-4, are also… (More)
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1998
1998
Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
The Expressed Sequence Tag database has been searched for examples of previously undescribed human Alpha class glutathione… (More)
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