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GSTA4 gene

Known as: glutathione S-transferase alpha 4, Glutathione S-Transferase Alpha 4 Gene, GLUTATHIONE S-TRANSFERASE A4 
This gene is involved in the metabolism of small molecules and xenobiotics.
National Institutes of Health

Related topics

Related topics

4 relations
Biogenic Amine Metabolic ProcessGSTA4 protein, humanGlutathione S-Transferasexenobiotic metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
Drug metabolizing enzymes (DMEs) and drug transporters are regulated via epigenetic, transcriptional, posttranscriptional, and… 
2012
2012
The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4.
2012
2012
Loss of glutathione S‐transferase A4 accelerates obstruction‐induced tubule damage and renal fibrosis
Glutathione transferase isozyme A4 (GSTA4) exhibits high catalytic efficiency to metabolize 4‐hydroxynonenal (4‐HNE), a highly… 
2009
2009
Expression level and DNA methylation status of glutathione‐S‐transferase genes in normal murine prostate and TRAMP tumors
Glutathione‐S‐transferase (Gst) genes are downregulated in human prostate cancer, and GSTP1 silencing is mediated by promoter DNA… 
2006
2006
The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice.
Highly Cited
2003
Highly Cited
2003
Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans.
The genetic basis of disease susceptibility can be studied by several means, including research on animal models and… 
2002
2002
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides.
In this study, human glutathione transferases (GSTs) of alpha class have been assayed with the ultimate carcinogenic (-)-anti… 
2001
2001
Immunohistological Analysis of Glutathione Transferase A4 Distribution in Several Human Tissues Using a Specific Polyclonal Antibody
We examined the cellular distribution of glutathione transferase A4 (GSTA4) in various human tissues by indirect immunoperoxidase… 
2001
2001
(S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats.
In guinea-pig liver cytosol, racemic 4-hydroxy-2(E)-nonenal (HNE), a reactive and highly toxic product released from biomembranes… 
1996
1996
Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells.
It has previously been suggested that adriamycin (doxorubicin, DOX), which is used to treat various types of malignancies, exerts… 
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