GS-9219
National Institutes of Health
Papers overview
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Tanovea® (first named GS-9219, then VDC-1101, generic name: rabacfosadine) is a pro-prodrug or “double” prodrug of PMEG [9-(2…
GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG) has significant activity as…
BackgroundMultiple myeloma (MM) is an important human and canine cancer for which novel therapies remain necessary. VDC-1101…
Background Canine cutaneous T‐cell lymphoma (CTCL) is an uncommon disease for which efficacious therapies are lacking. The novel…
BACKGROUND/AIM
GS 9219 is a double prodrug of antiproliferative nucleotide analog 9-(2-Phosphonylmethoxyethyl)guanine (PMEG…
Spontaneous cancers are common in the pet dog population with estimated 60% of dogs that live to 10 years of age developing…
Purpose: GS-9219 is a cell-permeable prodrug of the acyclic nucleotide analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG); the…
Acyclic nucleoside phosphonates PMEDAP and PMEG modulate expression of selected proangiogenic genes in SD-lymphoma bearing rats…
Purpose: GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG), was designed as a…
3290 GS-9219 is a novel nucleoside analogue that was designed based on a double-prodrug approach applied to limit plasma exposure…